Antiviral resistance surveillance in Japan (as of January 17, 2014)

Details
[Background and objective]
  Japan is the world's biggest consumer of four neuraminidase inhibitors, oseltamivir, peramivir, zanamivir and laninamivir, for chemotherapy against influenza and has a high potential to emerge the inhibitor-resistant influenza viruses.  Consequently, sustained monitoring of the neuraminidase inhibitor-resistant viruses and sharing surveillance data are important for public health measures and therapeutic strategy at clinical hospitals.
  To monitor neuraminidase inhibitor-resistant influenza viruses, we tested A(H1N1)pdm09, A(H3N2) and B viruses by a combination of phenotypic and genotypic assays.  In the phenotypic assay, approximately 5-10% of total isolates were randomly selected and subjected to neuraminidase inhibition assays against oseltamivir, peramivir, zanamivir and laninamivir.  In the genotypic assay, allele-specific TaqMan RT-PCR and/or partial sequencing of neuraminidase gene were performed to detect antiviral resistance mutations.

The data summarized below are results of phenotypic and genotypic assays reported and updated monthly.

 

2013/2014 influenza season (Sep. 2013-Aug. 2014)

(as of Jan 17, 2014) NEW
Table 1. Detection of antiviral drug-resistant viruses in Japan, [A(H1N1)pdm09, A(H3N2), B]
Table 2. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by prefecture
Table 3. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by week

2012/2013 influenza season (Sep. 2012-Aug. 2013)

(as of Dec 26, 2013)

Table 1. Detection of antiviral drug-resistant viruses in Japan, [A(H1N1)pdm09, A(H3N2), B]
Table 2. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by prefecture
Table 3. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by week

2011/2012 influenza season (Sep. 2011-Aug. 2012)

(as of April 11, 2013) 
Table 1. Detection of antiviral drug-resistant viruses in Japan, [A(H1N1)pdm09, A(H3N2), B]
Table 2. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by prefecture
Table 3. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by week

2010/2011 influenza season (Sep. 2010-Aug. 2011)

(as of February 6, 2013)
Table 1. Detection of antiviral drug-resistant viruses in Japan, [A(H1N1)pdm09, A(H3N2), B]
Table 2. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by prefecture
Table 3. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by week

2009/2010 influenza season (Sep. 2009-Aug. 2010)

(as of February 6, 2013)
Table 1. Detection of antiviral drug-resistant viruses in Japan, [A(H1N1)pdm09, A(H3N2), B]
Table 2. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by prefecture
 logo-e Laboratory of influenza virus surveillance and WHO Collaborating Center 
for Reference and Research on Influenza, Tokyo, Japan 
at Influenza Virus Research Center, 
National Institute of Infectious Diseases and
the Influenza Virus Surveillance Group of Japan

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Copyright 1998 National Institute of Infectious Diseases, Japan