Antiviral resistance surveillance in Japan (as of September 26, 2016)

[Background and objective]

Japan is the world's biggest consumer of four neuraminidase inhibitors, oseltamivir, peramivir, zanamivir and laninamivir, for chemotherapy against influenza and has a high potential to emerge the inhibitor-resistant influenza viruses. Consequently, sustained monitoring of the neuraminidase inhibitor-resistant viruses and sharing surveillance data are important for public health measures and therapeutic strategy at clinical hospitals.
To monitor neuraminidase inhibitor-resistant influenza viruses, we tested A(H1N1)pdm09, A(H3N2) and B viruses by a combination of phenotypic and genotypic assays. In the phenotypic assay, approximately 5-10% of total isolates were randomly selected and subjected to neuraminidase inhibition assays against oseltamivir, peramivir, zanamivir and laninamivir. In the genotypic assay, allele-specific TaqMan RT-PCR and/or partial sequencing of neuraminidase gene were performed to detect antiviral resistance mutations.

The data summarized below are results of phenotypic and genotypic assays reported.


	2015/2016 influenza season (Sep. 2015-Aug. 2016) (as of September 26, 2016) *NEW*
		Table 1. Detection of antiviral drug-resistant viruses in Japan, [A(H1N1)pdm09, A(H3N2), B]
		Table 2. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by prefecture
		Table 3. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by week

	2014/2015 influenza season (Sep. 2014-Aug. 2015) (as of March 04, 2016)
		Table 1. Detection of antiviral drug-resistant viruses in Japan, [A(H1N1)pdm09, A(H3N2), B]
		Table 2. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by prefecture
		Table 3. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by week

	2013/2014 influenza season (Sep. 2013-Aug. 2014) (as of April 23, 2015)
		Table 1. Detection of antiviral drug-resistant viruses in Japan, [A(H1N1)pdm09, A(H3N2), B]
		Table 2. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by prefecture
		Table 3. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by week

	2012/2013 influenza season (Sep. 2012-Aug. 2013) (as of March 10, 2014)
		Table 1. Detection of antiviral drug-resistant viruses in Japan, [A(H1N1)pdm09, A(H3N2), B]
		Table 2. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by prefecture
		Table 3. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by week

	2011/2012 influenza season (Sep. 2011-Aug. 2012) (as of April 11, 2013)
		Table 1. Detection of antiviral drug-resistant viruses in Japan, [A(H1N1)pdm09, A(H3N2), B]
		Table 2. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by prefecture
		Table 3. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by week

	2010/2011 influenza season (Sep. 2010-Aug. 2011) (as of February 6, 2013)
		Table 1. Detection of antiviral drug-resistant viruses in Japan, [A(H1N1)pdm09, A(H3N2), B]
		Table 2. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by prefecture
		Table 3. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by week

	2009/2010 influenza season (Sep. 2009-Aug. 2010) (as of February 6, 2013)
		Table 1. Detection of antiviral drug-resistant viruses in Japan, [A(H1N1)pdm09, A(H3N2), B]
		Table 2. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by prefecture

Laboratory of influenza virus surveillance and WHO Collaborating Center
for Reference and Research on Influenza, Tokyo, Japan
at Influenza Virus Research Center,
National Institute of Infectious Diseases and
the Influenza Virus Surveillance Group of Japan

Go to Flash report of influenza virus in Japan