国立感染症研究所


  To monitor antiviral-resistant influenza viruses, we tested A(H1N1)pdm09, A(H3N2) and B viruses by a combination of phenotypic and genotypic assays.  In the phenotypic assay, approximately 10–20% of total isolates were randomly selected and subjected to a neuraminidase (NA) inhibition assay for NA inhibitors, oseltamivir, peramivir, zanamivir, and laninamivir, or a focus reduction assay for baloxavir marboxil.  In the genotypic assay, allele-specific TaqMan RT-PCR and/or sequencing of NA, PA, and M2 genes were performed to detect antiviral resistance mutations.

 

The data summarized below are results of phenotypic and genotypic assays reported.

   
   2018/2019 influenza season (Sep. 2018-Aug. 2019)

(as of May 31, 2019) NEW

    Table 1. Detection of antiviral drug-resistant viruses in Japan, [A(H1N1)pdm09, A(H3N2), B]
    Table 2. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by prefecture
    Table 3. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by week
   
   2017/2018 influenza season (Sep. 2017-Aug. 2018)

(as of May 20, 2019) 

    Table 1. Detection of antiviral drug-resistant viruses in Japan, [A(H1N1)pdm09, A(H3N2), B]
    Table 2. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by prefecture
    Table 3. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by week
   
   2016/2017 influenza season (Sep. 2016-Aug. 2017)

(as of July 2, 2018)  

    Table 1. Detection of antiviral drug-resistant viruses in Japan, [A(H1N1)pdm09, A(H3N2), B]
    Table 2. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by prefecture
    Table 3. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by week
   
 

2015/2016 influenza season (Sep. 2015-Aug. 2016)

(as of August 4, 2017)   

    Table 1. Detection of antiviral drug-resistant viruses in Japan, [A(H1N1)pdm09, A(H3N2), B]
    Table 2. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by prefecture
    Table 3. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by week
     
 

2014/2015 influenza season (Sep. 2014-Aug. 2015)

(as of March 4, 2016)   

    Table 1. Detection of antiviral drug-resistant viruses in Japan, [A(H1N1)pdm09, A(H3N2), B]
    Table 2. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by prefecture
    Table 3. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by week
     
 

2013/2014 influenza season (Sep. 2013-Aug. 2014)

(as of April 23, 2015)

    Table 1. Detection of antiviral drug-resistant viruses in Japan, [A(H1N1)pdm09, A(H3N2), B]
    Table 2. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by prefecture
    Table 3. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by week
     
 

2012/2013 influenza season (Sep. 2012-Aug. 2013)

(as of March 10, 2014)

    Table 1. Detection of antiviral drug-resistant viruses in Japan, [A(H1N1)pdm09, A(H3N2), B]
    Table 2. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by prefecture
    Table 3. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by week
     
 

2011/2012 influenza season (Sep. 2011-Aug. 2012)

(as of April 11, 2013) 

    Table 1. Detection of antiviral drug-resistant viruses in Japan, [A(H1N1)pdm09, A(H3N2), B]
    Table 2. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by prefecture
    Table 3. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by week
     
 

2010/2011 influenza season (Sep. 2010-Aug. 2011)

(as of February 6, 2013)

    Table 1. Detection of antiviral drug-resistant viruses in Japan, [A(H1N1)pdm09, A(H3N2), B]
    Table 2. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by prefecture
    Table 3. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by week
     
 

2009/2010 influenza season (Sep. 2009-Aug. 2010)

(as of February 6, 2013)

    Table 1. Detection of antiviral drug-resistant viruses in Japan, [A(H1N1)pdm09, A(H3N2), B]
    Table 2. Detection of A(H1N1)pdm09 viruses with H275Y mutation in Japan, Report by prefecture
     
 logo-e Laboratory of influenza virus surveillance and WHO Collaborating Center 
for Reference and Research on Influenza, Tokyo, Japan 
at Influenza Virus Research Center, 
National Institute of Infectious Diseases and
the Influenza Virus Surveillance Group of Japan

Copyright 1998 National Institute of Infectious Diseases, Japan

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