国立感染症研究所

Department of Virology I

The Department of Virology I is engaged in research, the quality control of vaccines, and reference activities related to hemorrhagic fever viruses, arboviruses, neuroviruses, herpesviruses, Rickettsia and Chlamydia. The research is directed towards (i) biological characterization of viruses, Rickettsia and Chlamydia, (ii) the development of laboratory diagnostic methods, (iii) molecular and sero-epidemiology, (iv) disease pathogenesis, and (v) the development of new vaccines.

LABORATORY OF SPECIAL PATHOGENS
  • Laboratory diagnosis and virological studies on hemorrhagic fever viruses including Ebola, Marburg, Lassa, and Crimean-Congo hemorrhagic fever viruses and variola virus.
  • Molecular study on the pathogenesis of hantaviruses.
  • Development of diagnostic laboratory methods for emerging and re-emerging viral diseases.
  • Reference laboratory activities on poxviruses.
LABORATORY OF ARBOVIRUSES
  • Development of diagnostic laboratory methods for arbovirus infections.
  • Molecular epidemiological studies on arboviruses.
  • Studies on the immune responses induced by arbovirus infection and vaccination.
  • Quality control of Japanese encephalitis vaccine.
  • Quality control of yellow fever vaccine.
  • Reference laboratory activity on arboviruses.
  • This laboratory has been designated as a global specialized laboratory by WHO.
LABORATORY OF NEUROVIROLOGY
  • Molecular pathogenesis of rabies virus.
  • Molecular epidemiological studies on lyssaviruses.
  • Development of new rabies vaccine and quality control of the current vaccine.
  • Laboratory diagnosis of progressive multifocal leukoencephalopathy.
  • Pathophysiological study on polyomavirus infections.
LABORATORY OF HERPESVIRUSES
  • Studies on prophylaxis, treatment, and diagnosis of the diseases caused by human herpesviruses.
  • Studies on replication, gene expression, and pathogenesis of human herpesviruses.
  • Molecular and sero-epidemiology of human herpes-viruses.
  • Studies on live varicella zoster virus (VZV) vaccine and VZV intradermal test antigen for quality control of these products.
LABORATORY OF RICKETTSIA AND CHLAMYDIA
  • Development of diagnostic laboratory methods for rickettsial and chlamydial infections.
  • Molecular and sero-epidemiological studies on Rickettsia and Chlamydia.
  • Study of the pathogenesis of rickettsial and chlamydial infections.
  • Reference laboratory activities on Rickettsia and Chlamydia.

Copyright 1998 National Institute of Infectious Diseases, Japan

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