Jpn. J. Infect. Dis., 56. 70-72, 2003

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Short Communication

Heat Stability of the Lyophilized Sabin Poliovaccine

Hiroshi Shiomi, Tomoko Urasawa*1 and Shozo Urasawa*

Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan

(Received February 26, 2003. Accepted May 1, 2003)

SUMMARY: In this study we lyophilized three types of live attenuated polioviruses (Sabin vaccine strains) and evaluated the lyophilized vaccine viruses' heat stability. The virus titers were measured after heating at 37Ž and 45Ž and then compared with the titers of conventional liquid vaccine viruses similarly treated. The results showed that lyophilization, while slightly reducing vaccine virus titers, had a far greater sparing effect on subsequent heat inactivation of lyophilized vaccine viruses, thus demonstrating its validity for the improvement of the vaccine.


*1Present address: Department of Liberal Arts and Sciences, Tenshi College, N13 E3, Higashi-ku, Sapporo 065-0013, Japan.

*Corresponding author: Mailing address: Faculty of Human Ecology, Fuji WomenÕs University, Minami 4-5, Hanakawa, Ishikari 061-3204, Japan. Tel: +81-133-74-3111, E-mail: urasawa@fujijoshi.ac.jp

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