Jpn. J. Infect. Dis., 57, 119-120, 2004

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Short Communication

Contribution of Exotoxin A of Pseudomonas aeruginosa in Acute and Chronic Experimental Renal Infection

Saroj Sharma*, Ramanjeet Kaur, Vanashree Yadav, Kusum Harjai and Kusum Joshi¹

Department of Microbiology, Panjab University and ¹Department of Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

(Received December 25, 2003. Accepted March 30, 2004)

*Corresponding author: Mailing address: Department of Microbiology, Basic Medical Sciences Building, Panjab University, Sector-14, Chandigarh- 160014, India. E-mail: vanashree_y@yahoo.com

SUMMARY: The role of Pseudomonas aeruginosa exotoxin A was studied in acute and chronic pyelonephritis models employing an exotoxin A-producing strain PAO, and its toxin deficient mutant PAOT1. Interestingly, the mutant strain was found to be at an advantage in its ability to induce acute pyelonephritis and it induced severer renal pathology. No significant differences were observed in the ability of the parent strain and its mutant to induce chronic renal inflammation.

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