Jpn. J. Infect. Dis., 57, 273-275, 2004
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Short Communication
Antimicrobial Susceptibility of Isolates
from Neonatal Septicemia
Nalini Agnihotri, Neelam Kaistha, and Varsha Gupta*
Department of Microbiology, Government Medical College Hospital,
Chandigarh 160 031, India
(Received March 12, 2004. Accepted July 13, 2004)
*Corresponding author: Mailing address: Department of Microbiology,
Government Medical College Hospital, Chandigarh 160 031, India.
Tel: +172-2665253-59 Ext.1061, Fax: +172-2609360, 2608488,
E-mail: varshagupta_99@yahoo.com
SUMMARY: A retrospective study of bacterial isolates from
cases of neonatal septicemia was undertaken over a period of 5
years (July 1998 - June 2003) at the Government Medical College
Hospital, Chandigarh, India. The study was carried out to determine
the bacterial profile, the antimicrobial susceptibility of the
isolates, and the change in trends over the study period. A total
of 3,064 blood samples for blood culture were obtained, out of
which 588 were positive for bacterial isolates. Most of the cases
detected by blood culture occurred in the first week of life (64.4%).
Gram-negative bacilli (58.5%) predominated over Gram-positive
cocci (41.5%). Staphylococcus aureus was found to be the
most common isolate (35.0%).The incidence of Gram-positive and
Gram-negative organisms changed little over the 5 year span. However,
a constant and significant rise in the incidence of Acinetobacter
spp. was observed between the first to fifth year of the study
period. Amikacin was found to be the most effective drug against
Gram-negative bacteria. For S. aureus and Pseudomonas
aeruginosa, overall resistance percentages of 5 years show
that netilmicin and ciprofloxacin, respectively, were the most
effective drugs.
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