Jpn. J. Infect. Dis., 57, S1-S2, 2004
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Contribution of Peroxidases in Host-Defense,
Diseases and Cellular Functions
Kazuo Suzuki*, Eri Muso1
and William M. Nauseef2
National Institute of Infectious Diseases, Tokyo, 1Kitano
Hospital Medical Research Institute, Osaka, Japan; 2University
of Iowa and Veterans Administration Medical Center, Iowa, USA
*Corresponding author: ksuzuki@nih.go.jp
SUMMARY: Peroxidases figure prominently in biology and contribute
significantly to cell biology, host defense against infection,
and pathogenesis of several inflammatory diseases. These varied
and diverse aspects of peroxidase biochemistry and its clinical
implications will be the subjects of in-depth analysis at the
4th International peroxidase meeting held in Kyoto. Specific topics
range from the molecular basis of peroxidase structure and function
to the clinical consequences of autoantibodies generated against
myeloperoxidase (MPO), the peroxidase present in circulating neutrophils.
Consideration of novel aspects of peroxidase biology, both unanticipated
biochemical properties of MPO and the potential role of MPO in
the pathogenesis of inflammatory diseases such as atherosclerosis,
will also be included. In addition to peroxidases, the newly expanded
family of NADPH oxidases will be discussed. We hope that this
collection of scientists who share a common interest in peroxidase
biology but each possess expertise in distinctly different aspects
of the subject will provide a setting for spirited discussion
and a lively exchange of views to yield advances in understanding
and to create new applications of those insights to benefit clinical
medicine, agriculture and industry.