Jpn. J. Infect. Dis., 58, 125-130, 2005
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The Interaction of HIV-1 with the Host Factors
Jun Komano*, Yuko Futahashi, Emiko Urano, Kosuke Miyauchi, Tsutomu Murakami, Zene Matsuda and Naoki Yamamoto
AIDS Research Center, National Institute of Infectious Diseases, Tokyo 208-0011, Japan
(Received December 3, 2004)
*Corresponding author: Mailing address: Laboratory of Virology
and Pathogenesis, AIDS Research Center, National Institute of
Infectious Diseases, 4-7-1 Gakuen, Musashi-Murayama, Tokyo 208-0011,
Japan.
Tel: +81-42-561-0771 ext. 335, Fax: +81-42-562-7875, E-mail: ajkomano@nih.go.jp
CONTENTS:
1. Introduction
2. Cellular entry molecules
3. From the epidemiologic study
4. Restriction factors
5. Binding partners
6. Other cellular factors
7. Concluding remarks
SUMMARY: Human immunodeficiency virus type 1 (HIV-1) is a causative agent of acquired immunodeficiency syndrome (AIDS) in humans. In the last decade, the functions of HIV-1-encoded genes have been intensively studied. These studies have contributed to the development of the effective anti-AIDS drugs directing against the HIV-1-encoded enzymes, namely reverse transcriptase and protease. However, even the combination of these drugs is not sufficient enough to stop the progression of AIDS partly due to the emergence of drug-resistant HIV-1 mutants as well as the severe side effects. Understanding the molecular mechanisms by which cellular factors support the efficient replication of HIV-1 should contribute to develop means to control the progression of AIDS. This field is now expanding rapidly. Here we review the host factors involved in the replication of HIV-1 and highlight some findings that have a substantial impact on the retroviral research.