Jpn. J. Infect. Dis., 58, 159-161, 2005

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Original Article

Increasing Antimicrobial Resistance in Escherichia coli Isolates from Community-Acquired Urinary Tract Infections during 1998 - 2003 in Manisa, Turkey

Semra Kurutepe*, Suheyla Surucuoglu, Cenk Sezgin, Horu Gazi, Mehmet Gulay and Beril Ozbakkaloglu

Department of Microbiology and Clinical Microbiology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey

(Received November 12, 2004. Accepted February 2, 2005)


*Corresponding author: Mailing address: M Kemal Cad No:128/6, Bornova, Izmir, Turkey. Tel: +90-2362331920, Fax: +90-2362331466, E-mail: semrakurutepe@yahoo.com


SUMMARY: Urinary tract infections are among the most common infections with an increasing resistance to antimicrobials. The aim of this study was to determine the change in antimicrobial susceptibility of Escherichia coli isolates from patients with community-acquired urinary tract infection (UTI) for the years 1998 through 2003 and to suggest that the current empirical antibiotic therapy used for these patients is inappropriate. During the study period, 7,335 community urine samples of which 1,203 (16.4%) grew bacterial isolates were analyzed. Among the total of 1,203 isolates, 880 (73.2%) were E. coli. The range of resistance of E. coli to ampicillin was 47.8 to 64.6% and that to trimethoprim-sulfamethoxazole was 37.1 to 44.6% during the study period. The susceptibility pattern of E. coli to nitrofurantoin and cefuroxime did not vary significantly over the 6-year period. There was a significant increase in the susceptibility of E. coli to ciprofloxacin (11.3 - 26.7%), amoxicillin-clavulanate (18.4 - 29.2%) and gentamicin (7.0 - 25.6%) (P < 0.05). Empirical initial treatment with ampicillin and trimethoprim-sulfamethoxazole was thus inadequate in approximately half of UTI cases in our region.


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