Jpn. J. Infect. Dis., 58, 31-33, 2005
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Short Communication
Interaction of Yersinia enterocolitica Biotype 1A Strains of Diverse Origin with Cultured Cells In Vitro
Itender Singh and Jugsharan S. Virdi*
Department of Microbiology, University of Delhi South Campus,
New Delhi 110 021, India
(Received June 8, 2004. Accepted September 4, 2004)
*Corresponding author: Mailing address: Department of Microbiology,
University of Delhi South Campus, Benito Juarez Road, New Delhi
- 110 021, India. Tel: +91-11-26879950, Fax: +91-11-26885270,
E-mail: virdi_dusc@rediffmail.com
SUMMARY: Yersinia enterocolitica biotype 1A isolates
are increasingly being associated with diarrhea. However, the
mechanism of their pathogenicity is not well understood. In the
present study interaction of Y. enterocolitica isolates
with CHO cells, HEp-2 cells, and J774 mouse macrophages was studied.
Y. enterocolitica biotype 1A strains of clinical origin
invaded CHO and HEp-2 cells to a significantly higher degree than
non-clinical isolates. However, among non-clinical isolates, Y.
enterocolitica strains of swine origin showed significantly
more invasion in CHO and HEp-2 cells than water isolates. Y.
enterocolitica isolates from clinical samples exhibited a
greater level of survival in macrophages than isolates from non-clinical
sources. It may be construed that Y. enterocolitica biotype
1A isolates of clinical and swine origin have higher virulence
potential than those from other sources.