Jpn. J. Infect. Dis., 59 (2), 117-119, 2006
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Short Communication
Nalidixic Acid Resistance in Salmonella Strains with Decreased Susceptibility to Ciprofloxacin Isolated from Humans in Turkey
Serpil Ercis*, Birsel Erdem1, Gulsen Hascelik and Deniz Gur2
Department of Microbiology and Clinical Microbiology, Hacettepe University Faculty of Medicine, 1Department of Microbiology and Clinical Microbiology, Ankara University Faculty of Medicine, and; 2Ihsan Dogramaci Children's Hospital, Clinical Microbiology Laboratory, Ankara, Turkey
(Received September 12, 2005. Accepted December 28, 2005)
*Corresponding author: Mailing address: Hacettepe University, Faculty of Medicine, Department of Microbiology and Clinical Microbiology, Sihhiye 06100, Ankara, Turkey. Tel: +90-312-305-1560, Fax: +90-312-311-5250, E-mail: sercis@hacettepe.edu.tr
SUMMARY: The aim of this study was to evaluate the value of nalidixic acid resistance as an indicator of decreased susceptibility to ciprofloxacin (MIC = 0.125 - 1 mg/L) in Salmonella isolates from humans (n = 620) in Turkey. One isolate was found to be resistant, and the remaining isolates were susceptible to ciprofloxacin with the Clinical and Laboratory Standards Institute breakpoints; however, 75 isolates (12.1%) had decreased susceptibility. Resistance to nalidixic acid was observed in 76 (12.3%) isolates in the disk diffusion test. Seventy-four of these isolates had decreased susceptibility, one was fully resistant, and one isolate was susceptible to ciprofloxacin. One isolate with decreased susceptibility to ciprofloxacin was intermediate to nalidixic acid. Screening with 30-ƒÊg nalidixic acid disks had a sensitivity of 98.6% and a specificity of 99.8% for determination of decreased susceptibility to ciprofloxacin.