Jpn.J.Infect.Dis., 52, 110-112, 1999
Invited Minireview
SUMMARY: Epstein-Barr virus (EBV) infection is found
in 7% of Japanese gastric carcinoma. Our strategy is to establish
the EBV infected epithelial cell lines from EBV infected gastric
carcinomas and to characterize the cell lines on the bases of
cellular and molecular biology to define the etiological role
of EBV. We have characterized two EBV positive cell lines, GT38
and GT39 from gastric tissues. The both cell lines were EBV latency
type III and produced the virus spontaneously. The character of
tumor cells was demonstrated by the colony formation in soft agar
and the tumorigenesis in severe combined immunodeficient mice.
Corresponding author: E-mail:sairen@grape.med.tottori-u.ac.jp, Fax +81- 859-34-8042
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