Jpn. J. Infect. Dis., 53 (1), 17-19, 2000

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Short Communication

Molluscicidal　Saponins from Anagallis arvensis against Schistosome Intermediate Hosts

Mahfouz M. Abdel-Gawad, Samir M. El-Amin, Hajime Ohigashi¹, Yoshinori Watanabe¹, Naohito Takeda², Hiromu Sugiyama³ and Masanori Kawanaka^3*

Theodor Bilharz Research Institute, El-Nile Street, Warrak El-Hadar, Imbaba, Giza, Egypt, ¹Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa, Oiwake-cho, Kyoto 606-8502, ²Faculty of Pharmacy, Meijo University, Yagotoyama 150, Tempaku-ku, Nagoya, 468-8503 and ³Department of Parasitology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjyuku-ku, Tokyo 162-8640, Japan

(Received January 26, 2000. Accepted March 10, 2000)

SUMMARY: The molluscicidal activity of saponins isolated from the plant Anagallis arvensis (Primulaceae) was studied against schistosome intermediate hosts, Biomphalaria glabrata and Oncomelania quadrasi.　Strong molluscicidal activity was found in two compounds called desglucoanagalloside B and anagalloside B. Their structures were identified on the basis of chemical and spectroscopic analyses and their activities are comparable to that of the synthetic molluscicide, niclosamide.

*Corresponding author: Tel:+81-3-5285-1111 (ext.2734), Fax: +81-3-5285-1173, E-mail:mkawan@nih.go.jp

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