印刷

鳥インフルエンザA(H7N9)ウイルスによる感染事例に関するリスクアセスメントと対応

平成26年3月28日現在
国立感染症研究所

 

背景

 以下のリスクアセスメントは、現時点で得られている情報に基づいており、事態の展開があれば、リスクアセスメントを更新していく予定である。

 

疫学的所見

1)事例の概要

2)臨床情報

3)感染源・感染経路

4)環境調査

5)日本における調査

ウイルス学的所見

日本国内の対応

リスクアセスメントと今後の対応 

 

参考文献

  1. Gao H-N, Lu H-Z, Cao B, et al. Clinical Findings in 111 Cases of Influenza A (H7N9) Virus Infection. N Engl J Med 2013; 368: 130522140047004.
  2. Ip DKM, Liao Q, Wu P, et al. Detection of mild to moderate influenza A/H7N9 infection by China’s national sentinel surveillance system for influenza-like illness: case series. BMJ 2013; 346: f3693.
  3. Xiang N, Havers F, Chen T, et al. Use of national pneumonia surveillance to describe influenza A(H7N9) virus epidemiology, China, 2004-2013. Emerg Infect Dis. 2013 Nov;19(11):1784-90. doi: 10.3201/eid1911.130865.
  4. Hu Y, Lu S, Song Z, et al. Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance. Lancet 2013. doi:10.1016/S0140-6736(13)61125-3.
  5. Yu L, Wang Z, Chen Y, et al. Clinical, virological, and histopathological manifestations of fatal human infections by avian influenza A(H7N9) virus. Clin Infect Dis 2013. doi:10.1093/cid/cit541.
  6. Liu S, Sun J, Cai J, et al. Epidemiological, clinical and viral characteristics of fatal cases of human avian influenza A (H7N9) virus in Zhejiang Province, China. J Infect. 2013 Dec;67(6):595-605. doi: 10.1016/j.jinf.2013.08.007. Epub 2013 Aug 16.
  7. Han J, Jin M, Zhang P, et al. Epidemiological link between exposure to poultry and all influenza A(H7N9) confirmed cases in Huzhou city, China, March to May 2013. Euro surveill 2013; 18.http://www.ncbi.nlm.nih.gov/pubmed/23725866
  8. Cowling BJ, Jin L, Lau EHY, et al. Comparative epidemiology of human infections with avian influenza A H7N9 and H5N1 viruses in China: a population-based study of laboratory-confirmed cases. Lancet 2013; 382: 129–37.
  9. Yang S, Chen Y, Cui D, et al. Avian-origin H7N9 virus infection in H7N9-affected areas of China: a serological study. J Infect Dis 2013. doi:10.1093/infdis/jit224.
  10. Li Q, Zhou L, Zhou M, et al. Preliminary Report: Epidemiology of the Avian Influenza A (H7N9) Outbreak in China. N Engl J Med  2013. doi:10.1056/NEJMoa1304617.
  11. Qi X, Qian Y-H, Bao C-J, et al. Probable person to person transmission of novel avian influenza A (H7N9) virus in Eastern China, 2013: epidemiological investigation. BMJ 2013; 347: f4752.
  12. Lv H, Han J, Zhang P, Lu Y, et al. Mild illness in avian influenza A(H7N9) virus-infected poultry worker, Huzhou, China, April 2013. Emerg Infect Dis. 2013 Nov;19(11):1885-8. doi: 10.3201/eid1911.130717.
  13. Yu H, Wu JT, Cowling BJ,et al. Effect of closure of live poultry markets on poultry-to-person transmission of avian influenza A H7N9 virus: an ecological study. Lancet 2013; 383: 541-548.
  14. Watanabe T, Kiso M, Fukuyama S, et al. Characterization of H7N9 influenza A viruses isolated from humans. Nature 2013. doi:10.1038/nature12392.
  15. Lam TT, WangJ,Shen Y, et al. The genesis and source of the H7N9influenza viruses causing human infections in China. Nature 2013. doi:10.1038/nature12515
  16. Kageyama T, Fujisaki S, Takashita E, et al. Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013. Euro Surveill 2013; 18:20453-68
  17. Xiong X, Martin S, Haire LF, et al. Receptor binding by an H7N9 influenza virus from humans. Nature 2013. doi:10.1038/nature12372
  18. Tharakaraman K, Jayaraman A, Raman R, et al. Glycan receptor binding of the influenza A virusH7N9 hemagglutinin. Cell 2013; 153: 1-8.
  19. Belser JA, Gustin KM, Pearce MB, et al. Pathogenesis and transmission of avian influenza A(H7N9) virus in ferrets and mice. Nature 2013; doi: 10.1038/nature 12391.
  20. Yen H, Mckimm-Breschkin JL, Choy K, etal. Resistance to neuraminidase inhibitors conferred by an R292K mutation in a human influenza virus H7N9 isolate can be masked by a mixted R/K viral population. Mbio 2013; 4 e00396-13; 1-8.
  21. Lin PH, Chao TL, Kuo SW,et al. Virological, serological, and anti-viral studies of an imported human case of avian-influenza A [H7N9] virus in Taiwan. Clin Infect Dis. 2013 Sep
  22. Richard M, Schrauwen EJA, Graaf MD,et al. Limited airborn transmission of H7N9 influenza A virus between ferrets. Nature 2013. doi: 10.1038/nature12476.
Copyright 1998 National Institute of Infectious Diseases, Japan