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[35] Hanada K, Hara T, Fukasawa M, Yamaji A, Umeda M, Nishijima M (1998) Mammalian cell mutants resistant to a sphingomyelin-directed cytolysin. Genetic and biochemical evidence for complex formation of the LCB1 protein with the LCB2 protein for serine palmitoyltransferase, J Biol Chem, 273, 33787-33794. (Open access: http://www.jbc.org/content/273/50/33787.long)

[36] Hanada K, Hara T, Nishijima M (2000) Purification of the serine palmitoyltransferase complex responsible for sphingoid base synthesis by using affinity peptide chromatography techniques, J Biol Chem, 275, 8409-8415. (Open access: http://www.jbc.org/content/275/12/8409.long)

[37] Hanada K, Mitamura T, Fukasawa M, Magistrado PA, Horii T, Nishijima M (2000) Neutral sphingomyelinase activity dependent on Mg2+ and anionic phospholipids in the intraerythrocytic malaria parasite Plasmodium falciparum, Biochem J, 346 Pt 3, 671-677. (Open access: http://www.biochemj.org/bj/346/0671/bj3460671.htm)

[38] Bejaoui K, Uchida Y, Yasuda S, Ho M, Nishijima M, Brown RH, Jr., Holleran WM, Hanada K (2002) Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis, J Clin Invest, 110, 1301-1308. doi: 10.1172/JCI16450.

[39] Yasuda S, Nishijima M, Hanada K (2003) Localization, topology, and function of the LCB1 subunit of serine palmitoyltransferase in mammalian cells, J Biol Chem, 278, 4176-4183. doi: 10.1074/jbc.M209602200. (Open access: http://www.jbc.org/content/278/6/4176.long).

 

 

 

感染研 細胞化学部 花田賢太郎

 2013210日)

 2014331 改訂)(2016年10月18 図1::GlcCer構造図改訂)(2017年1 月13 余談1追加

2018年11月19 図1:Dihydroceramide desaturase反応改訂)

 

 

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*Hanada K (2014) Co-evolution of sphingomyelin and the ceramide transport protein CERT,

Biochim Biophys Acta, 1841, 704-719. doi: 10.1016/j.bbalip.2013.06.006 [Corrigendum (2014) 1841, 1561-1562; doi: 10.1016/j.bbalip.2014.08.002].

 

 

 

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