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治療薬・ワクチン開発研究センター 第三室

令和3年10月15日
治療薬・ワクチン開発研究センター
(内線2134)

第三室(自然免疫室)では、ワクチンに関する自然免疫学的研究を行っています。


研究テーマ

  1. COVID-19に関する自然免疫学的研究
  2. 劇症型溶血性レンサ球菌感染症に関する自然免疫学的研究
  3. はぶ、まむし、やまかがし、セアカゴケグモ抗毒素等の品質管理に関する研究

第三室の構成

  • [室長] 松村 隆之
  • [研究員] 高野 智弘
  • [協力研究員] 西山 紋惠(医薬基盤・健康・栄養研究所 特任研究員)
  • [派遣職員] 小林 多美
  • [臨時研究補助員] 浅野 千幸
  • 主な研究業績(2010年~)

    1. Lu X, Hosono Y, Nagae M, Ishizuka S, Ishikawa E, Motooka D, Ozaki Y, Sax N, Maeda Y, Kato Y, Morita T, Shinnakasu R, Inoue T, Onodera T, Matsumura T, Shinkai M, Sato T, Nakamura S, Mori S, Kanda T, Nakayama EE, Shioda T, Kurosaki T, Takeda K, Kumanogoh A, Arase H, Nakagami H, Yamashita K, Takahashi Y, Yamasaki S✉. Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients. J Exp Med. 2021 Dec 6;218(12):e20211327. doi: 10.1084/jem.20211327.
    2. Ono-Ohmachi A, Yamada S, Uno S, Tamai M, Soga K, Nakamura S, Udagawa N, Nakamichi Y, Koide M, Morita Y, Takano T, Itoh T, Kakuta S, Morimoto C, Matsuoka S, Iwakura Y, Tomura M, Kiyono H, Hachimura S, Nakajima-Adachi H✉. Effector memory CD4+T cells in mesenteric lymph nodes mediate bone loss in food-allergic enteropathy model mice, creating IL-4 dominance. Mucosal Immunol. 2021 Jul 29. doi: 10.1038/s41385-021-00434-2.
    3. Miki S, Sasaki H✉, Horiuchi H, Miyata N, Yoshimura Y, Miyazaki K, Matsumura T, Takahashi Y, Suzuki T, Matano T, Kawana-Tachikawa A, Tachikawa N. On-admission SARS-CoV-2 RNAemia as a single potent predictive marker of critical condition development and mortality in COVID-19. PLoS One. 2021 Jul 13;16(7):e0254640. doi: 10.1371/journal.pone.0254640.
    4. Moriyama S, Adachi Y, Sato T, Tonouchi K, Sun L, Fukushi S, Yamada S, Kinoshita H, Nojima K, Kanno T, Tobiume M, Ishijima K, Kuroda Y, Park ES, Onodera T, Matsumura T, Takano T, Terahara K, Isogawa M, Nishiyama A, Kawana-Tachikawa A, Shinkai M, Tachikawa N, Nakamura S, Okai T, Okuma K, Matano T, Fujimoto T, Maeda K, Ohnishi M, Wakita T, Suzuki T, Takahashi Y✉. Temporal maturation of neutralizing antibodies in COVID-19 convalescent individuals improves potency and breadth to circulating SARS-CoV-2 variants. Immunity. 2021 Aug 10;54(8)1841-1852.e4. doi: 10.1016/j.immuni.2021.06.015.(概要はこちら
    5. Anzurez A, Naka I, Miki S, Hosoya-Nakayama K, Isshiki M, Watanabe Y, Nakamura-Hoshi M, Seki S, Matsumura T, Takano T, Onodera T, Adachi Y, Moriyama S, Terahara K, Tachikawa N, Yoshimura Y, Sasaki H, Horiuchi H, Miyata N, Miyazaki K, Koga M, Ikeuchi K, Nagai H, Saito M, Adachi E, Yotsuyanagi H, Kutsuna S, Kawashima A, Miyazato Y, Kinoshita N, Kouno C, Tanaka K, Takahashi Y, Suzuki T, Matano T, Ohashi J✉, Kawana-Tachikawa A✉. Association of HLA-DRB1*09:01 with severe COVID-19. HLA. 2021 Jul;98(1):37-42. doi: 10.1111/tan.14256.
    6. Morokuma K✉, Matsumura T, Yamamoto A, Sakai A, Hifumi T, Ato M, Takahashi M. Evaluation of the stability of Yamakagashi (Rhabdophis tigrinus) equine antivenom after 20 years storage. Trop Biomed. 2021 Jun 30;38(2):111-118. doi: 10.47665/tb.38.2.042.
    7. Zhou Y, Qiu W, Wang Y, Wang R, Takano T, Li X, Zhu Z, Nakajima-Adachi H, Tanokura M✉, Hachimura S✉, Miyakawa T✉. β-Elemene suppresses obesity-induced imbalance in the microbiota-gut-brain axis. Biomedicines. 2021 Jun 22;9(7):704. doi: 10.3390/biomedicines9070704.
    8. Takano T, Matsumura T✉, Adachi Y, Terahara K, Moriyama S, Onodera T, Nishiyama A, Kawana-Tachikawa A, Miki S, Hosoya-Nakayama K, Nakamura-Hoshi M, Seki S, Tachikawa N, Yoshimura Y, Miyata N, Horiuchi H, Sasaki H, Miyazaki K, Kinoshita N, Sudo T, Akiyama Y, Sato R, Suzuki T, Matano T, Takahashi Y✉. Myeloid cell dynamics correlating with clinical outcomes of severe COVID-19 in Japan. Int Immunol. 2021 Mar 31;33(4):241-247. doi: 10.1093/intimm/dxab005.(EDITOR'S CHOICEに選ばれました)
    9. Zhou Y, Takano T, Wang Y, Li X, Wang R, Wakatsuki Y, Nakajima-Adachi H, Tanokura M, Miyakawa T✉, Hachimura S✉. Intestinal regulatory T cell induction by β-elemene alleviates the formation of fat tissue-related inflammation. iScience. 2020 Nov 30;24(1):101883. doi: 10.1016/j.isci.2020.101883. eCollection 2021 Jan 22.
    10. Matsumura T✉, Takahashi Y. The role of myeloid cells in prevention and control of group A streptococcal infections. Biosaf Health. 2020 Sep; 2(3):130-134. doi: 10.1016/j.bsheal.2020.05.006.
    11. Matsumura T✉*, Nishiyama A*, Aiko M, Ainai A, Ikebe T, Chiba J, Ato M, Takahashi Y✉. An anti-perfringolysin O monoclonal antibody cross-reactive with streptolysin O protects against streptococcal toxic shock syndrome. BMC Res Notes. 2020 Sep 5;13(1):419. doi: 10.1186/s13104-020-05264-2. (*equally contributed)
    12. Takano T, Kotaki R, Park J, Yoshida T, Wakatsuki Y, Tanokura M, Miyakawa T, Takahashi K, Nakajima-Adachi H, Hachimura S✉. Age-dependent decrease in the induction of regulatory T cells is associated with decreased expression of RALDH2 in mesenteric lymph node dendritic cells. Front Immunol. 2020 Aug 11;11:1555. doi: 10.3389/fimmu.2020.01555.
    13. Nithichanon A, Chetchotisakd P, Matsumura T, Takahashi Y, Ato M, Sakagami T, Lertmemongkolchai G✉. Diagnosis of NTM active infection in lymphadenopathy patients with anti-interferon-gamma auto-antibody using inhibitory ELISA vs. indirect ELISA. Sci Rep. 2020 Jun 2;10(1):8968. doi: 10.1038/s41598-020-65933-x.
    14. Li X, Miyakawa T, Takano T, Nakajima-Adachi H, Tanokura M, Hachimura S✉. Induction of oral tolerance by pepsin-digested gliadin retaining T cell reactivity in a mouse model of wheat allergy. Int Arch Allergy Immunol. 2020;181(6):446-455. doi: 10.1159/000506945.
    15. Han K, Song H, Choi CW, Park S, Kang YS, Jung K, Lee BH, Takahashi Y, Matsumura T, Yamamoto A, Kim YJ, Jee S, Kim J✉. Standardization of the first Korean national reference standard for snake (Gloydius brevicaudus) antivenom. Toxicol Res. 2020 Apr 14; 36(4):407-413. doi: 10.1007/s43188-020-00047-0.
    16. Yamamoto M, Abe C, Wakinaga S, Sakane K, Yumiketa Y, Taguchi Y, Matsumura T, Ishikawa K, Fujimoto J, Semba K, Miyauchi M, Akiyama T, Inoue J✉. TRAF6 maintains mammary stem cells and promotes pregnancy-induced mammary epithelial cell expansion. Commun Biol. 2019 Aug 6;2:292. doi: 10.1038/s42003-019-0547-7.
    17. Yoshizawa S, Matsumura T, Ikebe T, Ichibayashi R, Fukui Y, Satoh T, Tsubota T, Honda M, Ishii Y, Tateda K, Ato M✉. Streptococcal toxic shock syndrome caused by β-hemolytic streptococci: Clinical features and cytokine and chemokine analyses of 15 cases. J Infect Chemother. 2019 May;25(5):355-361. doi: 10.1016/j.jiac.2019.01.006.
    18. Matsumura T✉, Ikebe T, Arikawa K, Hosokawa M, Aiko M, Iguchi A, Togashi I, Kai S, Ohara S, Ohara N, Ohnishi M, Watanabe H, Kobayashi K, Takeyama H, Yamasaki S, Takahashi Y, Ato M. Sequential sensing by TLR2 and Mincle directs immature myeloid cells to protect against invasive group A streptococcal infection in mice. Cell Rep. 2019 Apr 9;27(2):561-571.e6. doi: 10.1016/j.celrep.2019.03.056.(概要はこちら
    19. Imai T, Matsumura T*, Mayer-Lambertz S*, Wells CA, Ishikawa E, Butcher SK, Barnett TC, Walker MJ, Imamura A, Ishida H, Ikebe T, Miyamoto T, Ato M, Ohga S, Lepenies B, van Sorge NM, Yamasaki S✉. Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection. Proc Natl Acad Sci USA. 2018 Nov 6;115(45):E10662-E10671. doi: 10.1073/pnas.1809100115. (*equally contributed)
    20. Yamamoto A✉, Harano S, Shinya N, Nagano A, Miyatsu Y, Sawabe K, Matsumura T, Ato M, Takahashi M, Taki H, Hifumi T. Freeze-dried equine-derived redback spider antivenom: a local irritation study by intramuscular injection in rabbits and a repeated-dose toxicity study in rats. J Toxicol Pathol. 2018 Apr;31(2):105-112. doi: 10.1293/tox.2017-0053.
    21. Matsumura T, Mashiko R, Sato T, Itokawa K, Maekawa Y, Ogawa K, Isawa H, Yamamoto A, Mori S, Horita A, Ginnaga A, Miyatsu Y, Takahashi M, Taki H, Hifumi T, Sawabe K✉, Ato M✉. Venom and antivenom of the redback spider (Latrodectus hasseltii) in Japan. Part I. Venom extraction, preparation, and laboratory testing. Jpn J Infect Dis. 2018 Mar 22;71(2):116-121. doi: 10.7883/yoken.JJID.2017.291.
    22. Mori S✉, Horita A, Ginnaga A, Miyatsu Y, Sawabe K, Matsumura T, Ato M, Yamamoto A, Shibayama K, Arai S, Yamagishi T, Takahashi M, Taki H, Hifumi T. Venom and antivenom of the redback spider (Latrodectus hasseltii) in Japan. Part II. Experimental production of equine antivenom against the redback spider. Jpn J Infect Dis. 2017 Nov 22;70(6):635-641. doi: 10.7883/yoken.JJID.2017.125.
    23. Ikebe T✉, Matsumura T, Nihonmatsu H, Ohya H, Okuno R, Mitsui C, Kawahara R, Kameyama M, Sasaki M, Shimada N, Ato M, Ohnishi M. Spontaneous mutations in Streptococcus pyogenes isolates from streptococcal toxic shock syndrome patients play roles in virulence. Sci Rep. 2016 Jun 28;6:28761. doi: 10.1038/srep28761.
    24. Varney ME, Niederkorn M, Konno H, Matsumura T, Gohda J, Yoshida N, Akiyama T, Christie S, Fang J, Miller D, Jerez A, Karsan A, Maciejewski JP, Meetei RA, Inoue J, Starczynowski DT✉. Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling. J Exp Med. 2015 Oct 19;212(11):1967-1985. doi: 10.1084/jem.20141898. 
    25. Matsuzaki Y, Sugawara K, Nakauchi M, Takahashi Y, Onodera T, Tsunetsugu-Yokota Y, Matsumura T, Ato M, Kobayashi K, Shimotai Y, Mizuta K, Hongo S, Tashiro M, Nobusawa E✉. Epitope mapping of the hemagglutinin molecule of A/(H1N1)pdm09 influenza virus by using monoclonal antibody escape mutants. J Virol. 2014 Nov;88(21):12364-12373. doi: 10.1128/JVI.01381-14.
    26. Matsumura T, Kobayashi K, Ato M✉. Myeloid-derived suppressor cells (MDSCs) and their related cell subpopulations. The Research and Biology of Cancer I. 2013 Sep;155-172.
    27. Fukuda T*, Matsumura T*, Ato M, Hamasaki M, Nishiuchi Y, Murakami Y, Maeda Y, Yoshimori T, Matsumoto S, Kobayashi K, Kinoshita T, Morita YS✉. Critical roles for lipomannan and lipoarabinomannan in cell wall integrity of mycobacteria and pathogenesis of tuberculosis. mBio. 2013 Feb 19;4(1):e00472-12. doi: 10.1128/mBio.00472-12. (*equally contributed)
    28. Matsumura T, Ato M✉, Ikebe T, Ohnishi M, Watanabe H, Kobayashi K. Interferon-γ-producing immature myeloid cells confer protection against severe invasive group A Streptococcus infections. Nat Commun. 2012 Feb 14;3:678. doi: 10.1038/ncomms1677.(概要はこちら
    29. Ikebe T✉, Ato M, Matsumura T, Hasegawa H, Sata T, Kobayashi K, Watanabe H. Highly frequent mutations in negative regulators of multiple virulence genes in group A streptococcal toxic shock syndrome isolates. PLoS Pathog. 2010 Apr 1;6(4):e1000832. doi: 10.1371/journal.ppat.1000832.

    (✉ corresponding author)

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