Jpn. J. Infect. Dis., 65 (2), 162-166, 2012

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Bidur Prasad Chaulagain¹, Sook Jin Jang^1,2*, Gyun Yeol Ahn², So Yeon Ryu³, Dong Min Kim⁴, Geon Park², Won Yong Kim⁵, Jong Hee Shin⁶, Joong Ki Kook⁷, Seong-Ho Kang², Dae Soo Moon², and Young Jin Park²

¹Research Center for Resistant Cells, ²Department of Laboratory Medicine, ³Department of Preventive Medicine, and ⁴Department of Internal Medicine, Chosun University Medical School, Gwang-Ju; ⁵Department of Microbiology, Chung-Ang University College of Medicine, Seoul; ⁶Department of Laboratory Medicine, Chonnam University Medical School, Gwang-ju; and ⁷Department of Oral Biochemistry, College of Dentistry, Chosun University, Gwang-ju, Korea

(Received July 9, 2011. Accepted December 5, 2011)

*Corresponding author: Mailing address: Department of Laboratory Medicine, Research Center for Resistant Cells, Chosun University Medical School, 588 Seoseok-dong, Dong-gu, Gwangju 501-717, South Korea. Tel: +82(62)220-3259, 82-10-9614-8853, Fax: +82(62)232-2063, E-mail: このメールアドレスはスパムボットから保護されています。閲覧するにはJavaScriptを有効にする必要があります。

SUMMARY: Between January 2004 and December 2004, an outbreak of imipenem-resistant Acinetobacter baumannii (IRAB) in 2 intensive care units (ICU) of Chosun University Hospital, Korea affected 77 patients. A case-control study revealed that the time spent in the hospital and mechanical ventilation practices were risk factors. IRAB was isolated from the hands of 4% (5/124) of healthcare workers; 27.3% (21/77) of the samples obtained from the ICU environment. A pulsed-field gel electrophoresis analysis showed that 82.1% (23/28) of clinical IRAB isolates and 85.7% (6/7) of environmental IRAB isolates were type A. The ISAba1F/OXA-51-likeR PCR showed that 93.7% (30/32) of IRAB strains had the ISAba1 gene upstream of the bla_OXA-51-like gene. Two ISAba1F/OXA-51-likeR PCR-negative IRAB strains were bla_IMP-1 positive. All of the IRAB strains tested by PCR were negative for bla_VIM, bla_SIM, bla_GIM-1, bla_SPM-1, bla_GES, bla_OXA-23-like, blaOXA-24-like, and bla_OXA-58-like carbapenemase genes. After implementing an infection control strategy, a steady reduction in the attack rate of IRAB infection was observed.