Jpn. J. Infect. Dis., 65 (1), 66-71, 2012
To see a printable version of the article in the Adobe file format, click this [PDF] link.
Hande Aydemir1*, Guven Celebi1, Nihal Piskin1, Nefise Oztoprak1, Aysegul Seremet Keskin1, Elif Aktas2, Vildan Sumbuloglu3, and Deniz Akduman1
1Department of Infectious Diseases and Clinical Microbiology, 2Department of Microbiology, and 3Department of Biostatistics, Zonguldak Karaelmas University Medical Faculty, Zonguldak, Turkey
(Received January 24, 2011. Accepted October 25, 2011)
*Corresponding author: Mailing address: Department of Infectious Diseases and Clinical Microbiology, Zonguldak Karaelmas University Medical Faculty, 67600 Zonguldak, Turkey. Tel: +905383712756, Fax: +903722610264, E-mail: このメールアドレスはスパムボットから保護されています。閲覧するにはJavaScriptを有効にする必要があります。
SUMMARY: This study was performed to compare the mortality associated with carbapenem-resistant Acinetobacter baumannii (CRAB) and carbapenem-sensitive A. baumannii (CSAB) infections, to identify potential risk factors for CRAB infections, and to investigate the effects of potential risk factors on mortality in CRAB and CSAB patients. This retrospective case-control study was conducted in a university hospital between January 1, 2005 and December 30, 2006. One hundred and ten patients with CRAB and 55 patients with CSAB infection were identified during the study period. The mortality rate was 61.8% and 52.7% in CRAB and CSAB cases, respectively (P = 0.341). In CRAB cases, the risk factors for mortality were identified as intubation (odds ratio [OR], 3.3; 95% confidence interval [CI], 1.0–10.1; P = 0.042) and high APACHE II score (OR, 1.2; 95% CI, 1.1–1.3; P = 0.000), by multivariate analysis. Previous use of carbapenem (OR, 6.1; 95% CI, 2.2–17.1; P = 0.001) or aminopenicillin (OR, 2.5; 95% CI, 1.2–5.1; P = 0.013) were independently associated with carbapenem resistance. Although the mortality rate was higher among patients with CRAB infections, this difference was not found to be statistically significant. Previous use of carbapenem and aminopenicillin were found to be independent risk factors for infections with CRAB.
