1. Yamaji T, Kumagai K, Tomishige N, *Hanada K (2008) Two sphingolipid transfer proteins, CERT and FAPP2: their roles in sphingolipid metabolism, IUBMB Life, 60, 511-518. doi: 10.1002/iub.83. (Open access: http://onlinelibrary.wiley.com/doi/10.1002/iub.83/pdf)
  2. Tsuda K, Furuta N, Inaba H, Kawai S, Hanada K, *Yoshimori T, Amano A (2008) Functional analysis of alpha5beta1 integrin and lipid rafts in invasion of epithelial cells by Porphyromonas gingivalis using fluorescent beads coated with bacterial membrane vesicles, Cell Struct Funct, 33, 123-132.
  3. *Tanida I, Yamaji T, Ueno T, Ishiura S, Kominami E, Hanada K (2008) Consideration about negative controls for LC3 and expression vectors for four colored fluorescent protein-LC3 negative controls, Autophagy, 4, 131-134.
  4. *Separovic D, Semaan L, Tarca AL, Awad Maitah MY, Hanada K, Bielawski J, Villani M, Luberto C (2008) Suppression of sphingomyelin synthase 1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage, Exp Cell Res, 314, 1860-1868. doi: 10.1016/j.yexcr.2008.02.008.
  5. Saito S, Matsui H, Kawano M, Kumagai K, Tomishige N, Hanada K, Echigo S, *Tamura S, *Kobayashi T (2008) Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes, J Biol Chem, 283, 6584-6593. doi: 10.1074/jbc.M707691200.
  6. Okemoto-Nakamura Y, Yamakawa Y, Hanada K, Tanaka K, Miura M, Tanida I, Nishijima M, *Hagiwara K (2008) Synthetic fibril peptide promotes clearance of scrapie prion protein by lysosomal degradation, Microbiol Immunol, 52, 357-365. doi: 10.1111/j.1348-0421.2008.00046.x.
  7. Okemoto K, Hanada K, Nishijima M, *Kawasaki K (2008) The preparation of a lipidic endotoxin affects its biological activities, Biol Pharm Bull, 31, 1952-1954.
  8. *Maehama T, Tanaka M, Nishina H, Murakami M, Kanaho Y, Hanada K (2008) RalA functions as an indispensable signal mediator for the nutrient-sensing system, J Biol Chem, 283, 35053-35059. doi: 10.1074/jbc.M805822200.
  9. Kudo N, Kumagai K, Tomishige N, Yamaji T, *Wakatsuki S, Nishijima M, *Hanada K, Kato R (2008) Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide, Proc Natl Acad Sci U S A, 105, 488-493. doi: 10.1073/pnas.0709191105. (Open access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206563/)
  10. *Haruna K, Suga Y, Muramatsu S, Taneda K, Mizuno Y, Ikeda S, Ueno T, Kominami E, Tanida I, Tanida I, Hanada K (2008) Differentiation-specific expression and localization of an autophagosomal marker protein (LC3) in human epidermal keratinocytes, J Dermatol Sci, 52, 213-215. doi: 10.1016/j.jdermsci.2008.07.005.
  11. Haberkant P, Schmitt O, Contreras FX, Thiele C, Hanada K, Sprong H, Reinhard C, *Wieland FT, *Brugger B (2008) Protein-sphingolipid interactions within cellular membranes, J Lipid Res, 49, 251-262. doi: 10.1194/jlr.D700023-JLR200.
  12. Giussani P, Colleoni T, Brioschi L, Bassi R, Hanada K, Tettamanti G, Riboni L, *Viani P (2008) Ceramide traffic in C6 glioma cells: evidence for CERT-dependent and independent transport from ER to the Golgi apparatus, Biochim Biophys Acta, 1781, 40-51. doi: 10.1016/j.bbalip.2007.11.002.
  13. Charruyer A, Bell SM, Kawano M, Douangpanya S, Yen TY, Macher BA, Kumagai K, Hanada K, Holleran WM, *Uchida Y (2008) Decreased ceramide transport protein (CERT) function alters sphingomyelin production following UVB irradiation, J Biol Chem, 283, 16682-16692. doi: 10.1074/jbc.M800799200.
  14. Aizaki H, Morikawa K, Fukasawa M, Hara H, Inoue Y, Tani H, Saito K, Nishijima M, Hanada K, Matsuura Y, Lai MM, Miyamura T, Wakita T, *Suzuki T (2008) Critical role of virion-associated cholesterol and sphingolipid in hepatitis C virus infection, J Virol, 82, 5715-5724. doi: 10.1128/JVI.02530-07.


  1. Shi L, Bielawski J, Mu J, Dong H, Teng C, Zhang J, Yang X, Tomishige N, Hanada K, Hannun YA, *Zuo J (2007) Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis, Cell Res, 17, 1030-1040. doi: 10.1038/cr.2007.100.
  2. *Separovic D, Hanada K, Maitah MY, Nagy B, Hang I, Tainsky MA, Kraniak JM, Bielawski J (2007) Sphingomyelin synthase 1 suppresses ceramide production and apoptosis post-photodamage, Biochem Biophys Res Commun, 358, 196-202. doi: 10.1016/j.bbrc.2007.04.095.
  3. Sano O, Kobayashi A, Nagao K, Kumagai K, Kioka N, Hanada K, *Ueda K, Matsuo M (2007) Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1, J Lipid Res, 48, 2377-2384. doi: 10.1194/jlr.M700139-JLR200.
  4. Nagao K, Takahashi K, Hanada K, Kioka N, Matsuo M, *Ueda K (2007) Enhanced apoA-I-dependent cholesterol efflux by ABCA1 from sphingomyelin-deficient Chinese hamster ovary cells, J Biol Chem, 282, 14868-14874. doi: 10.1074/jbc.M611230200.
  5. Kumagai K, Kawano M, Shinkai-Ouchi F, Nishijima M, *Hanada K (2007) Interorganelle trafficking of ceramide is regulated by phosphorylation-dependent cooperativity between the PH and START domains of CERT, J Biol Chem, 282, 17758-17766. doi: 10.1074/jbc.M702291200. (Open access: http://www.jbc.org/content/282/24/17758.long)
  6. *Hanada K, Kumagai K, Tomishige N, Kawano M (2007) CERT and intracellular trafficking of ceramide, Biochim Biophys Acta, 1771, 644-653. doi: 10.1016/j.bbalip.2007.01.009.


  1. Valeva A, Hellmann N, Walev I, Strand D, Plate M, Boukhallouk F, Brack A, Hanada K, Decker H, *Bhakdi S (2006) Evidence that clustered phosphocholine head groups serve as sites for binding and assembly of an oligomeric protein pore, J Biol Chem, 281, 26014-26021. doi: 10.1074/jbc.M601960200.
  2. *Separovic D, Wang S, Awad Maitah MY, Hanada K, Kessel D (2006) Ceramide response post-photodamage is absent after treatment with HA14-1, Biochem Biophys Res Commun, 345, 803-808. doi: 10.1016/j.bbrc.2006.04.131.
  3. Okemoto K, Kawasaki K, Hanada K, Miura M, *Nishijima M (2006) A potent adjuvant monophosphoryl lipid A triggers various immune responses, but not secretion of IL-1beta or activation of caspase-1, J Immunol, 176, 1203-1208.
  4. Kawano M, Kumagai K, Nishijima M, *Hanada K (2006) Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT, J Biol Chem, 281, 30279-30288. doi: 10.1074/jbc.M605032200. (Open access: http://www.jbc.org/content/281/40/30279.long)
  5. *Hanada K (2006) Discovery of the molecular machinery CERT for endoplasmic reticulum-to-Golgi trafficking of ceramide, Mol Cell Biochem, 286, 23-31. doi: 10.1007/s11010-005-9044-z.
  6. Grimmer S, Spilsberg B, *Hanada K, Sandvig K (2006) Depletion of sphingolipids facilitates endosome to Golgi transport of ricin, Traffic, 7, 1243-1253. 10.1111/j.1600-0854.2006.00456.x.
  7. *Fukasawa M, Tanaka Y, Sato S, Ono Y, Nitahara-Kasahara Y, Suzuki T, Miyamura T, Hanada K, Nishijima M (2006) Enhancement of de novo fatty acid biosynthesis in hepatic cell line Huh7 expressing hepatitis C virus core protein, Biol Pharm Bull, 29, 1958-1961.
  8. Cheng ZJ, Singh RD, Sharma DK, Holicky EL, Hanada K, Marks DL, *Pagano RE (2006) Distinct mechanisms of clathrin-independent endocytosis have unique sphingolipid requirements, Mol Biol Cell, 17, 3197-3210. doi: 10.1091/mbc.E05-12-1101.


  1. Tse SM, Mason D, Botelho RJ, Chiu B, Reyland M, Hanada K, Inman RD, *Grinstein S (2005) Accumulation of diacylglycerol in the Chlamydia inclusion vacuole: possible role in the inhibition of host cell apoptosis, J Biol Chem, 280, 25210-25215. doi: 10.1074/jbc.M501980200.
  2. Spilsberg B, Hanada K, *Sandvig K (2005) Diphtheria toxin translocation across cellular membranes is regulated by sphingolipids, Biochem Biophys Res Commun, 329, 465-473. doi: 10.1016/j.bbrc.2005.02.005.
  3. Kumagai K, Yasuda S, Okemoto K, Nishijima M, Kobayashi S, *Hanada K (2005) CERT mediates intermembrane transfer of various molecular species of ceramides, J Biol Chem, 280, 6488-6495. 10.1074/jbc.M409290200. (Open access: http://www.jbc.org/content/281/40/30279.long)
  4. Harikumar KG, Puri V, Singh RD, Hanada K, Pagano RE, *Miller LJ (2005) Differential effects of modification of membrane cholesterol and sphingolipids on the conformation, function, and trafficking of the G protein-coupled cholecystokinin receptor, J Biol Chem, 280, 2176-2185. 10.1074/jbc.M410385200.
  5. *Hanada K (2005) Sphingolipids in infectious diseases, Jpn J Infect Dis, 58, 131-148. (Open access: https://www0.niid.go.jp/JJID/58/131.pdf)
  6. Dolgachev V, Oberley LW, Huang TT, Kraniak JM, Tainsky MA, Hanada K, *Separovic D (2005) A role for manganese superoxide dismutase in apoptosis after photosensitization, Biochem Biophys Res Commun, 332, 411-417. doi: 10.1016/j.bbrc.2005.04.141.

Copyright 1998 National Institute of Infectious Diseases, Japan

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