花田研究業績（2022-） - 2000-2004

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2004年

  1. Sawamura N, Ko M, Yu W, Zou K, Hanada K, Suzuki T, Gong JS, Yanagisawa K, *Michikawa M (2004) Modulation of amyloid precursor protein cleavage by cellular sphingolipids, J Biol Chem, 279, 11984-11991. doi: 10.1074/jbc.M309832200.
  2. Miura Y, Gotoh E, Nara F, Nishijima M, *Hanada K (2004) Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases, FEBS Lett, 557, 288-292 doi:10.1016/S0014-5793(03)01523-0 (Open access: http://www.sciencedirect.com/science/article/pii/S0014579303015230) [Correction, (2004) 565, 207; doi:10.1016/j.febslet.2004.04.001; Open access: http://www.sciencedirect.com/science/article/pii/S0014579304003965]
  3. Dolgachev V, Farooqui MS, Kulaeva OI, Tainsky MA, Nagy B, Hanada K, *Separovic D (2004) De novo ceramide accumulation due to inhibition of its conversion to complex sphingolipids in apoptotic photosensitized cells, J Biol Chem, 279, 23238-23249. doi: 10.1074/jbc.M311974200.
  4. Carracedo A, Geelen MJ, Diez M, Hanada K, Guzman M, *Velasco G (2004) Ceramide sensitizes astrocytes to oxidative stress: protective role of cannabinoids, Biochem J, 380, 435-440. doi: 10.1042/bj20031714.

2003年

  1. Yasuda S, Nishijima M, *Hanada K (2003) Localization, topology, and function of the LCB1 subunit of serine palmitoyltransferase in mammalian cells, J Biol Chem, 278, 4176-4183. doi: 10.1074/jbc.M209602200. (Open access: http://www.jbc.org/content/278/6/4176.long)
  2. Nakamura Y, Matsubara R, Kitagawa H, *Kobayashi S, Kumagai K, Yasuda S, *Hanada K (2003) Stereoselective synthesis and structure-activity relationship of novel ceramide trafficking inhibitors. (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide and its analogues, J Med Chem, 46, 3688-3695. doi: 10.1021/jm0300779.
  3. Nakamura M, Mori Y, Okuyama K, Tanikawa K, Yasuda S, Hanada K, *Kobayashi S　(2003) Chemistry and biology of khafrefungin. Large-scale synthesis, design, and structure-activity relationship of khafrefungin, an antifungal agent, Org Biomol Chem, 1, 3362-3376.
  4. *Hanada K, Nishijima M (2003) Purification of mammalian serine palmitoyltransferase, a hetero-subunit enzyme for sphingolipid biosynthesis, by affinity-peptide chromatography, Methods Mol Biol, 228, 163-174. doi: 10.1385/1-59259-400-X:163.
  5. *Hanada K, Kumagai K, Yasuda S, Miura Y, Kawano M, Fukasawa M, Nishijima M (2003) Molecular machinery for non-vesicular trafficking of ceramide, Nature, 426, 803-809. doi: 10.1038/nature02188.
  6. *Hanada K (2003) Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism, Biochim Biophys Acta, 1632, 16-30. doi:10.1016/S1388-1981(03)00059-3.
  7. Dolgachev V, Nagy B, Taffe B, Hanada K, *Separovic D (2003) Reactive oxygen species generation is independent of de novo sphingolipids in apoptotic photosensitized cells, Exp Cell Res, 288, 425-436.

2002年

  1. Wispriyono B, Schmelz E, Pelayo H, Hanada K, *Separovic D (2002) A role for the de novo sphingolipids in apoptosis of photosensitized cells, Exp Cell Res, 279, 153-165.
  2. *Lafont F, Tran Van Nhieu G, Hanada K, Sansonetti P, van der Goot FG (2002) Initial steps of Shigella infection depend on the cholesterol/sphingolipid raft-mediated CD44-IpaB interaction, EMBO J, 21, 4449-4457.
  3. *Hanada K, Palacpac NM, Magistrado PA, Kurokawa K, Rai G, Sakata D, Hara T, Horii T, Nishijima M, *Mitamura T (2002) Plasmodium falciparum phospholipase C hydrolyzing sphingomyelin and lysocholinephospholipids is a possible target for malaria chemotherapy, J Exp Med, 195, 23-34. (Open access: http://jem.rupress.org/content/195/1/23.long)
  4. Bejaoui K, Uchida Y, Yasuda S, Ho M, Nishijima M, Brown RH, Jr., Holleran WM, *Hanada K (2002) Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis, J Clin Invest, 110, 1301-1308. 10.1172/JCI16450. (Open access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151618/)

2001年

  1. Yasuda S, Kitagawa H, Ueno M, Ishitani H, Fukasawa M, Nishijima M, Kobayashi S, *Hanada K (2001) A novel inhibitor of ceramide trafficking from the endoplasmic reticulum to the site of sphingomyelin synthesis, J Biol Chem, 276, 43994-44002. doi: 10.1074/jbc.M104884200 (Open access: http://www.jbc.org/content/276/47/43994.long) [Errantum, (2013) 288, 24162; doi: 10.1074/jbc.A113.104884; Open access: http://www.jbc.org/content/288/33/24162.short]
  2. Miura Y, Hanada K, *Jones TL (2001) G(s) signaling is intact after disruption of lipid rafts, Biochemistry, 40, 15418-15423.
  3. *Kobayashi S, Mori K, Wakabayashi T, Yasuda S, Hanada K (2001) Convergent total synthesis of khafrefungin and its inhibitory activity of fungal sphingolipid syntheses, J Org Chem, 66, 5580-5584.
  4. Chatterjee S, Smith ER, Hanada K, Stevens VL, *Mayor S (2001) GPI anchoring leads to sphingolipid-dependent retention of endocytosed proteins in the recycling endosomal compartment, EMBO J, 20, 1583-1592. doi: 10.1093/emboj/20.7.1583.
  5. Ueno, M, Kitagawa H, , Ishitani H, Yasuda S, Hanada K, *Kobayashi S (2001) Catalytic enantioselective synthesis of a novel inhibitor of ceramide trafficking, (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide (HPA-12), Tetrahedron Lett. 42, 7863-7865.

2000年

  1. van Ooij C, Kalman L, van I, Nishijima M, Hanada K, Mostov K, *Engel JN (2000) Host cell-derived sphingolipids are required for the intracellular growth of Chlamydia trachomatis, Cell Microbiol, 2, 627-637.
  2. *Mitamura T, Hanada K, Ko-Mitamura EP, Nishijima M, Horii T (2000) Serum factors governing intraerythrocytic development and cell cycle progression of Plasmodium falciparum, Parasitol Int, 49, 219-229.
  3. *Hanada K, Nishijima M, Fujita T, Kobayashi S (2000) Specificity of inhibitors of serine palmitoyltransferase (SPT), a key enzyme in sphingolipid biosynthesis, in intact cells. A novel evaluation system using an SPT-defective mammalian cell mutant, Biochem Pharmacol, 59, 1211-1216.
  4. *Hanada K, Nishijima M (2000) Selection of mammalian cell mutants in sphingolipid biosynthesis, Methods Enzymol, 312, 304-317.
  5. *Hanada K, Mitamura T, Fukasawa M, Magistrado PA, Horii T, Nishijima M (2000) Neutral sphingomyelinase activity dependent on Mg2+ and anionic phospholipids in the intraerythrocytic malaria parasite Plasmodium falciparum, Biochem J, 346, 671-677. (Open access: http://www.biochemj.org/bj/346/0671/bj3460671.htm)
  6. *Hanada K, Hara T, Nishijima M (2000) D-Serine inhibits serine palmitoyltransferase, the enzyme catalyzing the initial step of sphingolipid biosynthesis, FEBS Lett, 474, 63-65. (Open access: http://www.sciencedirect.com/science/article/pii/S0014579300015799)
  7. *Hanada K, Hara T, Nishijima M (2000) Purification of the serine palmitoyltransferase complex responsible for sphingoid base synthesis by using affinity peptide chromatography techniques, J Biol Chem, 275, 8409-8415. (Open access: http://www.jbc.org/content/275/12/8409.long)
  8. Funakoshi T, Yasuda S, Fukasawa M, Nishijima M, *Hanada K (2000) Reconstitution of ATP- and cytosol-dependent transport of de novo synthesized ceramide to the site of sphingomyelin synthesis in semi-intact cells, J Biol Chem, 275, 29938-29945. 10.1074/jbc.M004470200. (Open access: http://www.jbc.org/content/275/39/29938.long)
  9. Fukasawa M, Nishijima M, Itabe H, Takano T, *Hanada K (2000) Reduction of sphingomyelin level without accumulation of ceramide in Chinese hamster ovary cells affects detergent-resistant membrane domains and enhances cellular cholesterol efflux to methyl-beta -cyclodextrin, J Biol Chem, 275, 34028-34034. doi: 10.1074/jbc.M005151200. (Open access: http://www.jbc.org/content/275/44/34028.long)

Copyright 1998 National Institute of Infectious Diseases, Japan