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花田業績リスト                                                       2024.3.22更新

・英文論文のみ記載(断りのない限り査読有)

・各論文の責任著者(corresponding author)には名前の左肩に*印をつけた。
・各論文のDigital Object Identifier (DOI)もわかる範囲で加えた。
・Open access(誰でもネットで全文ダウンロード可能)なものはなるべくURLを記載した。
Google Scholarで提示された総引用数=13,342、h-index= 64; i10-Index=150 (2024.3.22.時点)

 

2024年

  1. *Mizuike A,, Hanada K (2024) DGARM/C10orf76/ARMH3 for ceramide transfer zone at the endoplasmic reticulum-distal Golgi contacts, CONTACT, 7, article 25152564241239443. (invited review article) open access: https://journals.sagepub.com/doi/10.1177/25152564241239443

 

2023年

  1. *Someya K, Okemoto-Nakamura Y, Kurata T, Saito N, Itamochi M, Otsuki N, Hanada K, Takeda M (2023) Establishment of Measles virus receptor-expressing Vero cells lacking functional poliovirus receptors, Microbiol Immunol, 67, 166-170. doi: 10.1111/1348-0421.13047
  2. *Goto A, Hanada K: Protocols for casein kinase 1γ3 CSNK1G3 gene knockout and recombinant gene expression in cultured mammalian cells, STAR Protocols, 4, article 102251, 2023. Open access: https://doi.org/10.1016/j.xpro.2023.102251
  3. Charlotte Gehin, Museer A. Lone, Winston Lee, Laura Capolupo, Sylvia Ho, Adekemi Adeyemi, Erica H. Gerkes, Alexander P.A. Stegmann, Estrella López-Martín, Eva Bermejo-Sánchez, Beatriz Martínez-Delgado, Christiane Zweier, Cornelia Kraus, Bernt Popp, Vincent Strehlow, Daniel Gräfe, Ina Knerr, Eppie Jones, Stefano Zamuner, Luciano A. Abriata, Vidya Kunnathully, Brandon E. Moeller, Anthony Vocat, Samuel Rommelaere, Jean-Philippe Bocquete, Evelyne Ruchti, Greta Limoni, Marine Van Campenhoudt, Samuel Bourgeat, Petra Henklein, Christian Gilissen, Bregje W. van Bon, Rolph Pfundt, Marjolein Willemsen, Jolanda Schieving, Emanuela Leonardi, Fiorenza Soli, Alessandra Murgia, Hui Guo, Qiumeng Zhang, Kun Xia, Christina R. Fagerberg, Christoph P. Beier, Martin J. Larsen, Irene Valenzuela, Paula Fernández-Álvarez, Shiyi Xiong, Robert Śmigiel, Vanesa López-González, Lluís Armengol, Manuela Morleo, Angelo Selicorni, Annalaura Torella, Moira Blyth, Nicola Cooper, Valerie Wilson, Renske Oegema, Yvan Herenger, Aurore Garde, Ange-Line Bruel, Frederic Tran Mau-Them, Alexis B.R. Maddocks, Jennifer M. Bain, Musadiq A. Bhat, Gregory Costain, Peter Kannu, Ashish Marwaha, Neena L. Champaigne, Michael J. Friez, Ellen B Richardson, Vykuntaraju K. Gowda, Varunvenkat M. Srinivasan, Yask Gupta, Tze Y. Lim, Simone Sanna-Cherchi, Bruno Lemaitre, Toshiyuki Yamaji , Kentaro Hanada, John E. Burke, Ana Marjia Jaksic, Brian D. McCabe, Paolo De Los Rios, *Thorsten Hornemann, *Giovanni D’Angelo, and *Vincenzo A. Gennarino: CERT mutations perturb human development by disrupting sphingolipid homeostasis, J Clin Invest, 133, e165019, 2023. (Gehin C, Lone MA, and Lee W are co-first authors) Open access: 10.1172/JCI165019
  4. Mizuike A, Sakai S, Katoh K, Yamaji T, *Hanada K: The C10orf76-PI4KB axis orchestrates CERT-mediated ceramide trafficking to the distal Golgi, J Cell Biol, 222, e202111069, 2023. Open access :https://rupress.org/jcb/article/222/7/e202111069/214116

 

2022年

  1. *Sugiki T, Lee Y-H, Alsanousi N, Murata K; Kawamura I, Fujiwara T, Hanada K, *Kojima C (2022) A hybrid strategy combining solution NMR spectroscopy and isothermal titration calorimetry to characterize protein-nanodisc interaction, Anal Biochem, 639, article 114521. (T.S. & Y.-H. L. are co-first authors) Open access: https://doi.org/10.1016/j.ab.2021.114521
  2. *Hanada K, Sakai S, Kumagai K (2022) Natural ligand-mimetic and nonmimetic inhibitors of the ceramide transport protein CERT, Int J Mol Sci, 23, article 2098. (invited review article) Open access: https://doi.org/10.3390/ijms23042098
  3. Konishi K, Yamaji T, Sakuma C, Kasai F, Endo T, Kohara A, *Hanada K, *Osada N (2022) Whole-genome sequencing of Vero E6 (VERO C1008) and comparative analysis of four Vero cell sublines, Front Genetics, 13, article 801382. Open access: https://www.frontiersin.org/articles/10.3389/fgene.2022.801382/full
  4. Fujita J, Taniguchi M, Hashizume C, Ueda Y, Sakai S, Kondo T, Hashimoto-Nishimura M, Hanada K, Kosaka T, *Okazaki T (2022) Nuclear ceramide is associated with ATM activation in the neocarzinostatin-induced apoptosis of lymphoblastoid cells, Mol Pharmacol, 101, 322-333. Doi: 10.1124/molpharm.121.000379
  5. Shimasaki K, *Kumagai K, Sakai S, Yamaji T, *Hanada K (2022) Hyperosmotic stress induces phosphorylation of CERT and enhances its tethering throughout the endoplasmic reticulum, Int J Mol Sci, 23, article 4025. Open access: https://doi.org/10.3390/ijms23074025
  6. *Konan K, Ogbamikael SA, Yager E, Yamaji T, Cerone J, Monaco-Brown M, Barroso M, Hanada K (2022) Modulation of Zika virus replication via glucosylceramide synthase and glycosphingolipids, Virology, 572, 17-27. Doi: 10.1016/j.virol.2022.03.014
  7. *Hanada K (2022) Dysregulation of a lipid transfer protein linked to brain disorders, LIPID NEWS, ASBMB TODAY, April 12, 2022. Open access: https://www.asbmb.org/asbmb-today/science/041222/dysregulation-of-a-lipid-transfer-protein-linked-t (invited news article, non-peer-reviewed)
  8. Kobayashi J, *Arita M, Sakai S, Kojima H, Senda M, Senda T, Hanada K, *Kato R (2022) Ligand recognition by the lipid transfer domain of human OSBP is important for enterovirus replication, ACS Infect Dis, 8, 1161–1170. Doi:10.1021/acsinfecdis.2c00108
  9. Goto A, Sakai S, Mizuike A, Yamaji T, *Hanada K (2022) Compartmentalization of casein kinase 1 γ CSNK1G controls the intracellular trafficking of ceramide, iScience, 15, article 104624. Open access: https://doi.org/10.1016/j.isci.2022.104624.
  10. Goto A, Egawa D, *Tomishige N, Yamaji T, Kumagai K, *Hanada K (2022) Involvement of a cluster of basic amino acids in phosphorylation-dependent functional repression of the ceramide transport protein CERT, Int J Mol Sci, 23, article 8576. (A.G. and D.E. are co-first authors) Open access: https://doi.org/10.3390/ijms23158576
  11. *Saito K, Shimasaki K, Fukasawa M, Suzuki R, Okemoto-Nakamura Y, Katoh K, Takasaki T, Hanada K (2022) Establishment of Vero cell lines persistently harboring a yellow fever virus 17D subgenomic replicon, Virus Res, 322, article 198935. doi: 10.1016/j.virusres.2022.198935
  12. *Mori Y, Sakata M, Sakai S, Okamoto T, Nakatsu Y, Taguwa S, Otsuki N, Maeda Y, Hanada K, Matsuura Y, Takeda M (2022) Membrane sphingomyelin in host cells is essential for nucleocapsid penetration into the cytoplasm after hemifusion during rubella virus entry, mBio, 13, e01698-22. Open access: https://doi.org/10.1128/mbio.01698-22
  13. Shirasago Y, Fukazawa H, Nagase S, Shimizu Y, Wakita T, Suzuki T, Tani H, Kondoh M, Kuroda T, Yasuda S, Sato Y, Hanada K, *Fukasawa M (2022) A single mutation in the E2 glycoprotein of hepatitis C virus broadens the claudin specificity for its infection, Sci Rep, 12, article 20243. Open access: https://doi.org/10.1038/s41598-022-23824-3
  14. *Kumagai K, Sakai S, Ueno M, Kataoka M, Kobayashi S, *Hanada K (2022) Chlamydial infection-dependent synthesis of sphingomyelin as a novel anti-chlamydial target of ceramide-mimetic compounds, Int J Mol Sci, 23, article 14697. Open access: https://doi.org/10.3390/ijms232314697.

 

2021年までの論文業績に関しては下の「・次へ>>」をクリックして下さい)

 

花田の研究テーマな

  1. 私の志向する生化学、細生物学そして体細胞遺伝
  2. スフィンゴ脂質につい

III. 哺乳動物細胞におけるセラミド輸送に関する研

  1. 病原体による宿主脂質ハイジャック機序の解明と創薬への応
  2. 動物培養細胞に関する用語な
  3. Vero細胞の物語 ~その樹立からゲノム構造の決定、そして未来へ

 

花田研究業(このページ)

 

その他の記事

1.生命、細胞、生体

2. スフィンゴ脂質およびセラミドの命名事始め(外部サイトへリンク)

3. セラミド研究史概略(外部サイトへリンク)

 

 


2021年

 

  1. Shimizu Y, Shinoda T, Shirasago Y, Kondoh M, Shinya N, Hanada K, Yagi K, Suzuki T, Wakita T, Kimura-Someya T, Shirouzu M, and *Fukasawa M (2021) Generation and characterization of single-chain variable fragment occludin-binding antibodies to prevent hepatitis C virus infection, FEBS Let, 595, 220-229. doi: 10.1002/1873-3468.13975.
  2. Ogawa M, Shirasago Y, Tanida I, Kakuta S, Uchiyama Y, Shimojima M, Hanada K, Saijo M, and *Fukasawa M (2021)Structural basis of antiviral activity of caffeic acid against severe fever with thrombocytopenia syndrome virus, J Infect Chemother, 27, 397-400. doi: 10.1016/j.jiac.2020.10.015.
  3.  *Rizzo R, Russo D, Kurokawa K, Sahu P, Lombardi B, Supino D, Zhukovsky M, Vocat A, Pothukuchi P, Kunnathully V, Capolupo L, Boncompain G, Vitagliano C, Marino FZ, Aquino G, Montariello D, Henklein P, Mandrich L, Botii G, Clausen H, Mandel U, Yamaji T, Hanada K, Budillon A, Perez F, Parashuraman S, Hannun YA, Nakano A, Corda D, *D’Angelo G and *Luini A (2021) Golgi maturation-dependent glycoenzyme recycling controls glycosphingolipid biosynthesis and cell growth via GOLPH3. EMBO Journal. 2021, 40, e107238, Open access: https://www.embopress.org/doi/epdf/10.15252/embj.2020107238
  4. Okemoto-Nakamura Y, Someya K, Yamaji T, Saito K, Takeda M, and *Hanada K (2021) Poliovirus-nonsusceptible Vero cell line for the World Health Organization global action plan, Sci Rep, 11, article 6746. Open access: https://www.nature.com/articles/s41598-021-86050-3 (Y.O.-N.. and K.S. are co-first authors)
  5. Sakuma C, Sekizuka T, Kuroda M, Hanada K, and *Yamaji T (2021) Identification of SYS1 as a host factor required for Shiga toxin-mediated cytotoxicity in Vero cells, Int J Mol Sci, 22, article 4936. Open access: https://doi.org/10.3390/ijms22094936
  6. Yamanaka A, Matsuda M, Okabayashi T, Pitaksajjakul P, Ramasoota P, Saito K, Fukasawa M, Hanada K, Matsuura T, Muramatsu M, Shioda T, and *Suzuki R (2021) Seroprevalence of flavivirus neutralizing antibodies in Thailand by high-throughput neutralization assay: Endemic circulation of Zika virus before 2012, mSphere, 6, e00339-21. Open access: https://doi.org/10.1128/mSphere.00339-21 (A.Y. & M.M. are co-first authors)
  7. *Furuichi K, Hiraoka M, Hanada K, Fujiwara T, and *Kojima C (2021) Sequence requirements of the FFAT-like motif for specific binding to VAP-A are revealed by NMR, FEBS Lett, 595, 2248-2256. doi: 10.1002/1873-3468.14166.
  8. Tamura N, Sakai S, Martorell L, Colomé R, Mizuike A, Goto A, *Ortigoza-Escobar JD, and *Hanada K (2021) Intellectual disability-associated mutations in the ceramide transport protein gene CERT1 lead to aberrant function and subcellular distribution, J Biol Chem, 297, article 101338. Open access: https://doi.org/10.1016/j.jbc.2021.101338

2020

  1. Tachida Y, Kumagai K, Sakai S, Ando S, *Yamaji T, and *Hanada K (2020) Chlamydia trachomatis-infected human cells convert ceramide to sphingomyelin without sphingomyelin synthases 1 and 2. FEBS Let, 594, 519-529. doi.org/10.1002/1873-3468.13632
  2.   *Hanada K (2020) Organelle contacts: sub-organelle zones to facilitate rapid and accurate inter-organelle trafficking of lipids.Traffic, 21, 189-196. doi.org/10.1111/tra.12716  (invited commentary)
  3. Ueno M, Miyoshi N, Hanada K, and *Kobayashi S (2020) Three-component, one-pot tandem Sonogashira/Suzuki–Miyaura coupling reactions for the synthesis of a library of ceramide-transport protein inhibitors designed in silico, Asia J Org Chem, 9, 267-273. DOI: 10.1002/ajoc.201900689
  4. *Saito K, Fukasawa M, Shirasago Y, Suzuki R, Osada N, Yamaji T, Wakita T, Konishi E, and Hanada K (2020) Comparative characterization of flavivirus production in two cell lines: Human hepatoma-derived Huh7.5.1-8 and African green monkey kidney-derived Vero. PLoS ONE, 15, e0232274. https://doi.org/10.1371/journal.pone.0232274
  5.  Morimoto K, Suzuki N, Tanida I, Kakuta S, Furuta Y, Uchiyama Y, Hanada K, Suzuki Y, *Yamaj T (2020) Blood group P1 antigen-bearing glycoproteins are functional but less efficient receptors of Shiga toxin than conventional glycolipid-based receptors, J Biol Chem, 295, 9490-9501. doi: 10.1074/jbc.RA120.013926.
  6.  Goto A, Mizuike A, and *Hanada K (2020) Sphingolipid metabolism occurring at the ER-Golgi contact zone and its impact on membrane trafficking, CONTACT, 3, article 2515256420959514. Open access: 10.1177/2515256420959514 (invited review article) (A.G. and A.M. are co-first authors)
  7. Gewaid H, Aoyagi H, Arita M, Watashi K, Suzuki R, Sakai S, Kumagai K, Yamaji T, Fukasawa M, Kato F, Hishiki T, Mimata A, Sakamaki Y, Ichinose S, Hanada K, Muramatsu M, Wakita T, and *Aizaki (2020) Sphingomyelin is essential for the structure and function of the double-membrane vesicles in the viral RNA replication factories, double-membrane vesicles, J Virol, 94, e01080-20. https://doi.org/10.1128/JVI.01080-20.
  8. Kawamoto M, Yamaji T, Saito K, Shirasago Y, Satomura K, Endo T, Fukasawa M, *Hanada K, and *Osada N (2020) Identification of characteristic genomic markers in human hepatoma HuH-7 and Huh7.5.1-8 cell lines, Frontier in Genetics, 111, Article 546106. Open access: https://doi.org/10.3389/fgene.2020.546106
  9. Murakami H, Tamura N, Enomoto Y, Shimasaki K, *Kurosawa K, and *Hanada K (2020) Intellectual disability-associated gain-of-function mutations in CERT1 that encodes the ceramide transport protein CERT, PLoS ONE, 15, e0243980. (H.M. and N.T. are co-first authors. K.K. and K.H. are co-correspondence) Open access: https://doi.org/10.1371/journal.pone.0243980

 2019

  1. *Yamaji T, Sekizuka T, Tachida Y, Sakuma C, Kuroda M, and Hanada K (2019) A CRISPR screen identifies LAPTM4A and TM9SF proteins as glycolipid-regulating factors, iScience, 11, 409-424. doi.org/10.1016/j.isci.2018.12.039.
  2. Nakao N, Ueno M, Sakai S, Egawa D, Hanzawa H, Kawasaki S, Kumagai K, Suzuki M, *Kobayashi S, and *Hanada K (2019) Natural ligand-nonmimetic inhibitors to the lipid transfer protein CERT, Commun Chem, 2, article 20.doi: 10.1038/s42004-019-0118-3 (N.N., M.U., and S.S. are co-first authors) (open access: https://www.nature.com/articles/s42004-019-0118-3)
  3. Shirasago Y, Inamori Y, Suzuki T, Tanida I, Suzuki T, Sugiyama K, Wakita T, Hanada K, and *Fukasawa M (2019) Inhibition mechanisms of hepatitis C virus infection by caffeic acid and tannic acid, Biol Pharm Bull, 42, 770. doi:10.1248/bpb.b18-00970 (a Highlighted paper selected by Editor-in-Chief).
  4. Shimizu Y, Shirasago Y, Suzuki T, Hata T, Kondoh M, Hanada K, Yagi K, and *Fukasawa M (2019) Characterization of monoclonal antibodies recognizing each extracellular loop domain of occluding, J Biochem, 166, 297-308. doi: 10.1093/jb/mvz037
  5. *Yamaji T, Hanamatsu H, Sekizuka T, Kuroda M, Ohnishi M,Furukawa J, *Yahiro K,, and Hanada K (2019) A CRISPR screen using subtilase cytotoxin identifies SLC39A9 as a glycan-regulating factor, iScience, 15, 407-420. doi: 10.1016/j.isci.2019.05.005
  6.   *Kumagai K, and *Hanada K (2019) Structure, functions, and regulation of CERT, a lipid-transfer protein for the delivery of ceramide at the ER-Golgi membrane contact sites, FEBS Let, 593, 2366-2377. https://doi.org/10.1002/1873-3468.13511 (invited review) 
  7. *Osawa T, *Shimamura T, Saito K, Hasegawa Y, Ishii N, Nishida M, Kondo A, Anwar M, Tsuchida R,Hino S, Sakamoto A, Igarashi K, Saitoh K, Kato K, Endo K, Yamano S, Kanki Y, Matsumura Y, Minami T, Tanaka T, Anai M, Wada Y, Wanibuchi H, Hayashi M, Hamada A, Yoshida M, Yachida S, Nakao M, Sakai J, Aburatani H, Shibuya M, Hanada K, Miyano S, *Soga T, and *Kodama T (2019) Phosphoethanolamine accumulation protects cancer cells under glutamine starvation through downregulation of PCYT2. Cell Rep, 29, 89-103. doi.org/10.1016/j.celrep.2019.08.087
  8. *Okemoto-Nakamura Y, Tanida I, Yamaji T, *Hanada K, and Hagiwara K (2019) A PRNP-disrupted human neuroblastoma cell line and its stable transformants expressing human prion variants. BPB Rep, 2, 73-79. (Open access: https://www3.e-kenkyu.com/bpb-reports-online-journal/uploads/manuscript/file/38/2_73.pdf).

2018

  1. Sakuma C, Sekizuka T, Kuroda M, Kasai F, Saito K, Ikeda M, Yamaji T, *Osada N, and *Hanada K (2018) Novel endogenous simian retroviral integrations in Vero cells: implications for quality control of a human vaccine cell substrate, Sci Rep, 8, 644. (C.S. and T.S. are co-first authors. N.O. and K.H. are co-correspondence) doi: 10.1038/s41598-017-18934-2. (Open access: https://www.nature.com/articles/s41598-017-18934-2)
  2. Shimasaki K, Watanabe-Takahash M, Umeda M, Funamoto S, Saito Y, Noguchi N, Kumagai K, Hanada K, Tsukahara F, Maru Y, Shibata N, Naito M, and *Nishikawa K (2018) Pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy, Genes Cells, 23, 22-34. doi: 10.1111/gtc.12544.
  3. Otsuki N, Sakata M, Saito K, Okamoto K, Mori Y, *Hanada K, and *Takeda M (2018)  Both sphingomyelin and cholesterol in the host cell membrane are essential for Rubella virus entry. J Virol, 92, e01130-17. doi: 10.1128/JVI.01130-17.(selected as Spotlight)
  4. Shimizu Y, Shirasago Y, Kondoh M, Suzuki T, Wakita T, Hanada K, Yagi K, and *Fukasawa M (2018) Monoclonal antibodies against occludin completely prevented hepatitis C virus infection in a mouse model, J Virol, 92, e02258-17. doi:10.1128/JVI.02258-17. (selected as Spotlight)
  5. Sugiki T, Egawa D, Kumagai K, Kojima C, Fujiwara T, Takeuchi K, Shimada I, *Hanada K, and *Takahashi H (2018) Phosphoinositide binding by the PH domain in ceramide transfer protein (CERT) is inhibited by hyperphosphorylation of an adjacent serine-repeat motif, J Biol Chem, 293, 11206-11217. (T.S. and D.E. are co-first authors. K.H. and H.T. are co-correspondence) doi: 10.1074/jbc.RA118.002465.
  6. Ikeda M, Satomura K, Sekizuka T, Hanada K, Endo T, *Osada N (2018) Comprehensive phylogenomic analysis reveals a novel cluster of simian endogenous retroviral sequences in Colobinae monkeys, Am J Primatol, e22882. doi: 10.1002/ajp.22882.
  7. *Hanada K (2018) Lipid-transfer proteins rectify inter-organelle flux and accurately deliver lipids at membrane contact sites, J Lipid Res, 59, 1341-1366. doi:  org/10.1194/jlr.R085324 (Open access: http://www.jlr.org/content/59/8/1341.full.pdf+html(invited review)
  8. *Saito K, Otsuki N, Takeda M, and Hanada K (2018) Liposome flotation assay for studying interactions between Rubella virus particles and lipid membranes, Bio-Protocol, 8(16), e2983.
  9. Shirasago Y, Fukazawa H, Aizaki H, Suzuki T, Suzuki T, Sugiyama K, Wakita T, Hanada K, Abe R, *Fukasawa M (2018) Thermostable hepatitis C virus JFH1-derived variant isolated by adaptation to Huh7.5.1 cells, J Gen Virol, 99(10), 1407-1417. doi: 10.1099/jgv.0.001117.
  10. *Kumagai K, Elwell CA, Andoh S, Engel JN, *Hanada K (2018) Both the N- and C- terminal regions of the Chlamydial inclusion protein D (IncD) are required for interaction with the pleckstrin homology domain of the ceramide transport protein CERT, Biochem Biophys Res Commun, 505(4), 1070-1076. doi: 10.1016/j.bbrc.2018.09.168.

2017

  1. Tóth EA, Oszvald Á, Péter M, Balogh G, Osteikoetxea-Molnár A, Bozó T, Szabó-Meleg E, Nyitrai M, Derényi I, Yamaji T, Hanada K, Vígh L, and *Matkó J (2017) Nanotubes connecting B lymphocytes: High impact of differentiation-dependent lipid composition on their growth and mechanics, Biochim Biophys Acta, 1862, 991-1000. doi: 10.1016/j.bbalip.2017.06.011.
  2. *Hanada K (2017) Ceramide transport from the endoplasmic reticulum to the trans Golgi region at organelle membrane contact sites, in "Organelle Contact Sites: From Molecular Mechanism to Diseases" (Eds., Mitsuo Tagaya & Thomas Simmen), Series: Advances in Experimental Medicine and Biology, Vol.997, pp69-81, Springer. DOI: 10.1007/978-981-10-4567-7 (査読無し)
  3. *Hanada K, and Sugiki T (2017) In vitro assay to extract specific lipid types from phospholipid membranes using lipid-transfer proteins: a lesson from the ceramide transport protein CERT, in “Lipidomics” (Ed., Paul Wood), Series: Neuromethods, Vol.125, pp81-98, Springer. Doi: 10.1007/978-1-4939-6946-3_6.
  4. *Oh H, Shin J, Ato M, Ma X, Williams D, Han K, Kim YJ, Kang HG, Jung K, Hanada K, Ochiai M, Hug PV, Park S, and Ahn C (2017) Meeting report: The first meeting of the national control laboratories for vaccines and biologicals in the Western pacific in 2016, Osong Public Health Res Perspect, 8, 91-103. Doi: org/10.24171/j.phrp.2017.8.1.13

 2016

  1.  *Yamaji T, Horie A, Tachida Y, Sakuma C, Suzuki Y, Kushi Y, and Hanada K (2016) Role of intracellular lipid logistics in the preferential usage of very long chain-ceramides in glucosylceramide, Int J Mol Sci,17, 1761. doi: 10.3390/ijms17101761 
  2. Hernández-Tiedra S, Fabrias G, Salanueva IJ, Casas J, Dávila D, Montes RL, Antón Z, García-Taboada E, Salazar M, Lorente M, Nylandsted J, Armstrong J, López-Valero I, McKee CS, García-López R, Serrano A, Abad JL, Hanada K, Goñi FM, Guzmán M, Lovat P, Jäättelä M, Alonso A, and *Velasco G (2016) Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization, Autophagy,12, 2213-2229. doi: 10.1080/15548627.2016.1213927
  3. Shirasago Y, Shimizu Y, Tanida I, Suzuki T, Suzuki R, Sugiyama K, Wakita T, Hanada K, Yagi K, Kondoh M, and *Fukasawa M (2016) Occludin-knockout human hepatic Huh7.5.1-8-derived cells are completely resistant to hepatitis C virus infection, Biol Pharm Bull, 39, 839–848. doi: 10.1248/bpb.b15-01023

2015

  1. Sawada K, Sato T, Hamajima H, Jayakody NL, Hirata M, Yamashiro M, Tajima M, Mitsutake S, Nagao K, Tsuge K, Abe F, Hanada K, and *Kitagaki H (2015) Glucosylceramide contained in mold-cultured cereal confers membrane and flavor modification and stress tolerance to yeast during co-culture fermentation, Appl Environ Microbiol, 81, 3688-3698. doi:10.1128/AEM.00454-15
  2. *Fukasawa M, Nagase S, Shirasago Y, Iida M, Yamashita M, Endo K, Yagi K, Suzuki T, Wakita T, Hanada K, Kuniyasu H, and Kondoh M (2015) Monoclonal antibodies against extracellular domains of claudin-1 block hepatitis C virus infection in a mouse model, J Virol, 89, 4866-4879. doi: 10.1128/JVI.03676-14
  3. *Kang H, Xu M, Rodríguez VP, Mefed K, Hanada K, Ahn K, Gangakhedkar SJ, Pakzad SR, Prawahju EI, Lee N, Phumiamorn S, Nemec M, Meng S, Knezevic I (2015) Review of the current use and evaluation of cell substrates for producing biologicals in selected countries, Biologicals, 43, 153-157. doi: 10.1016/j.biologicals.2015.01.004
  4. Zhao Y, Ishigami M, Nagao K, Hanada K, Kono N, Arai H, Matsuo M, Kioka N, *Ueda K (2015) ABCB4 exports phosphatidylcholine in a sphingomyelin-dependent manner, J Lipid Res, 56, 644-652. doi: 10.1194/jlr.M056622
  5. Saito K, Suzuki T, Aizaki H, Hanada K, Wakita T, Nishijima M, *Fukasawa M (2015) Targeting cellular squalene synthase, an enzyme essential for cholesterol biosynthesis, is a potential antiviral strategy against hepatitis C virus. J Virol, 89, 2220-2232. doi:10.1128/JVI.03385-14
  6. *Yamaji T, and Hanada, K (2015) Sphingolipid metabolism and interorganellar transport: localization of sphingolipid enzymes and lipid transfer proteins, Traffic, 16, 101-122. doi: 10.1111/tra.12239
  7. Shirasago Y, Sekizuka T, Saito K, Suzuki T, Wakita W, Hanada K, Kuroda M, Abe R, *Fukasawa M (2015) Isolation and characterization of a Huh.7.5.1-derived cell clone highly permissive to hepatitis C virus. Jpn J Infect Dis, 68, 81-88. doi: 10.7883/yoken.JJID.2014.231
  8. Tanida I, Shirasago Y, Suzuki R, Abe R, Wakita T, Hanada K, and *Fukasawa M (2015) Inhibitory effects of caffeic acid, a coffee-related organic acid, on the propagation of hepatitis C virus, Jpn J Infect Dis, 68, 268-275. doi: 10.7883/yoken.JJID.2014.309

2014

  1. Osada N, Kohara A, Yamaji T, Hirayama N, Kasai F, Sekizuka T, Kuroda M, *Hanada K (2014) The genome landscape of the African green monkey kidney-derived Vero cell line, DNA Res, 21, 673-683. doi: 10.1093/dnares/dsu029 (N.O. and A.K. equally contributed to this paper, and thus are co-first authors) (Open access: http://dnaresearch.oxfordjournals.org/content/21/6/673)
  2. Khan I, Katikaneni DS, Han Q, Sanchez-Felipe L, Hanada K, Ambrose RL, Mackenzie JM, and *Konan KV (2014) Modulation of hepatitis C virus genome replication by glycosphingolipids and four-phosphate adaptor protein 2, J Virol, 88, 12276-12295. doi:10.1128/JVI.00970-14
  3. *Hanada K, Voelker D (co-guest editors) (2014) Interorganelle trafficking of lipids: preface for the thematic review series, Traffic, 15, 889-894. doi:10.1111_tra.12193 (Open access:: http://onlinelibrary.wiley.com/doi/10.1111/tra.12193/epdf)(本論文が掲載された号の表紙に花田の作成した図が採用された)
  4. *Ogawa M, *Fukasawa M, Satoh M, Hanada K, Saijo M, Uchiyama T, and Ando S (2014) The intracellular pathogen Orientia tsutsugamushi responsible for scrub typhus induces lipid droplet formation in mouse fibroblasts, Microbe Infect., 16, 962-966. doi: 10.1016/j.micinf.2014.09.004
  5. Sano O, Ito S, Kato R, Shimizu Y, Kobayashi A, Kimura Y, Kioka N, Hanada K, Ueda K, and *Matsuo M: ABCA1, ABCG1, and ABCG4 are distributed to distinct membrane meso-domains and disturb detergent-resistant domains on the plasma membrane, PLoS One, 9, e109886. doi: 10.1371/journal.pone.0109886
  6. Hasegawa Y, *Hayashi H, Naoi S, *Kondou H, Bessho K, Igarashi K, Hanada K, Nakao K, Kimura T, Konishi A, Nagasaka H, Miyoshi Y, Ozono K, Kusuhara H (2014) Intractable itch relieved by 4-phenylbutyrate therapy in patients with progressive familial intrahepatic cholestasis type 1, Orphanet J Rare Dis, 9, 89. doi:10.1186/1750-1172-9-89
  7. *Maehama T, Kawahara K, Nishio M, Suzuki A, Hanada K (2014) Nucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1, J Biol Chem, 289, 20802-20812. doi: 10.1074/jbc.M114.571893
  8. Kumagai K, Kawano-Kawada M, *Hanada K (2014) Phosphoregulation of the ceramide transport protein CERT at serine 315 in the interaction with VAMP-associated protein (VAP) for inter-organelle trafficking of ceramide in mammalian cells, J Biol Chem, 289, 10748-10760. Open access:https://doi.org/10748-10760. 10.1074/jbc.M113.528380
  9. *Yamaji T, *Hanada K (2014) Establishment of HeLa cell mutants deficient in sphingolipid-related genes by using TALENs, PLoS ONE, 9, e88124. 10.1371/journal.pone.0088124. (Open access: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0088124)
  10. Kajiwara K, Ikeda A, Aguilera-Romero A, Castillon GA, Kagiwada S, Hanada K, Riezman H, Muniz M, *Funato K (2014) Osh proteins regulate COPII-mediated vesicular transport of ceramide from the endoplasmic reticulum in budding yeast, J Cell Sci, 127, 376-387. 10.1242/jcs.132001.
  11. *Hanada K (2014) Co-evolution of sphingomyelin and the ceramide transport protein CERT, Biochim Biophys Acta, 1841, 704-719. doi: 10.1016/j.bbalip.2013.06.006 [Corrigendum (2014) 1841, 1561-1562; doi: 10.1016/j.bbalip.2014.08.002].


2013年

  1. *Maehama T, Fukasawa M, Date T, Wakita T, Hanada K (2013) A class II phosphoinositide 3-kinase plays an indispensable role in hepatitis C virus replication, Biochem Biophys Res Commun, 440, 150-156. doi: 10.1016/j.bbrc.2013.09.048.
  2. *Kukimoto I, Maehama T, Sekizuka T, Ogasawara Y, Kondo K, Kusumoto-Matsuo R, Mori S, Ishii Y, Takeuchi T, Yamaji T, Takeuchi F, Hanada K, Kuroda M (2013) Genetic variation of human papillomavirus type 16 in individual clinical specimens revealed by deep sequencing, PLoS One, 8, e80583. doi: 10.1371/journal.pone.0080583.
  3. *Hagiwara K, Hara H, Hanada K (2013) Species-barrier phenomenon in prion transmissibility from a viewpoint of protein science, J Biochem, 153, 139-145. doi: 10.1093/jb/mvs148.
  4. Pratt S, Wansadhipathi-Kannangara NK, Bruce CR, Mina JG, Shams-Eldin H, Casas J, Hanada K, Schwarz RT, Sonda S, *Denny PW, Sphingolipid synthesis and scavenging in the intracellular apicomplexan parasite, Toxoplasma gondii, Mol Biochem Parasitol, 187, 43-51. doi: 10.1016/j.molbiopara.2012.11.007.

2012年

  1. Abe M, Makino A, Hullin-Matsuda F, Kamijo K, Ohno-Iwashita Y, Hanada K, Mizuno H, Miyawaki A, *Kobayashi T (2012) A role for sphingomyelin-rich lipid domains in the accumulation of phosphatidylinositol-4,5-bisphosphate to the cleavage furrow during cytokinesis, Mol Cell Biol, 32, 1396-1407. doi: 10.1128/MCB.06113-11.
  2. Sugiki T, Takeuchi K, Yamaji T, Takano T, Tokunaga Y, Kumagai K, Hanada K, *Takahashi H, *Shimada I (2012) Structural basis for the Golgi association by the pleckstrin homology domain of the ceramide trafficking protein (CERT), J Biol Chem, 287, 33706-33718. doi: 10.1074/jbc.M112.367730.
  3. Kumagai K, Nishijima M, *Hanada K (2012) Reconstitution assay system for ceramide transport with semi-intact cells, Methods Cell Biol, 108, 117-129. doi: 10.1016/B978-0-12-386487-1.00006-7.
  4. Hullin-Matsuda F, Tomishige N, Sakai S, Ishitsuka R, Ishii K, Makino A, Greimel P, Abe M, Laviad EL, Lagarde M, Vidal H, Saito T, Osada H, Hanada K, Futerman AH, *Kobayashi T (2012) Limonoid compounds inhibit sphingomyelin biosynthesis by preventing CERT protein-dependent extraction of ceramides from the endoplasmic reticulum, J Biol Chem, 287, 24397-24411. doi: 10.1074/jbc.M112.356733.
  5. Hara H, Okemoto-Nakamura Y, Shinkai-Ouchi F, Hanada K, Yamakawa Y, *Hagiwara K (2012) Mouse prion protein (PrP) segment 100 to 104 regulates conversion of PrP(C) to PrP(Sc) in prion-infected neuroblastoma cells, J Virol, 86, 5626-5636. doi: 10.1128/jvi.06606-11.

2011年

  1. Tuuf J, Kjellberg MA, Molotkovsky JG, Hanada K, *Mattjus P (2011) The intermembrane ceramide transport catalyzed by CERT is sensitive to the lipid environment, Biochim Biophys Acta, 1808, 229-235. doi: 10.1016/j.bbamem.2010.09.011.
  2. Elwell CA, Jiang S, Kim JH, Lee A, Wittmann T, Hanada K, Melancon P, *Engel JN (2011) Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development, PLoS Pathog, 7, e1002198. doi: 10.1371/journal.ppat.1002198.

2010年

  1. *Yamaji T, Nishikawa K, Hanada K (2010) Transmembrane BAX inhibitor motif containing (TMBIM) family proteins perturbs a trans-Golgi network enzyme, Gb3 synthase, and reduces Gb3 biosynthesis, J Biol Chem, 285, 35505-35518. doi: 10.1074/jbc.M110.154229.
  2. Tanaka M, Hara H, Nishina H, Hanada K, Hagiwara K, *Maehama T (2010) An improved method for cell-to-cell transmission of infectious prion, Biochem Biophys Res Commun, 397, 505-508. doi: 10.1016/j.bbrc.2010.05.143.
  3. Sugiki T, Takahashi H, Nagasu M, Hanada K, *Shimada I (2010) Real-time assay method of lipid extraction activity, Anal Biochem, 399, 162-167. doi: 10.1016/j.ab.2009.12.031.
  4. Shinkai-Ouchi F, Yamakawa Y, Hara H, Tobiume M, Nishijima M, Hanada K, *Hagiwara K (2010) Identification and structural analysis of C-terminally truncated collapsin response mediator protein-2 in a murine model of prion diseases, Proteome Sci, 8, 53. doi: 10.1186/1477-5956-8-53.
  5. *Separovic D, Kelekar A, Nayak AK, Tarca AL, Hanada K, Pierce JS, Bielawski J (2010) Increased ceramide accumulation correlates with downregulation of the autophagy protein ATG-7 in MCF-7 cells sensitized to photodamage, Arch Biochem Biophys, 494, 101-105. doi: 10.1016/j.abb.2009.11.023.
  6. Rivier AS, Castillon GA, Michon L, Fukasawa M, Romanova-Michaelides M, Jaensch N, Hanada K, *Watanabe R (2010) Exit of GPI-anchored proteins from the ER differs in yeast and mammalian cells, Traffic, 11, 1017-1033. doi: 10.1111/j.1600-0854.2010.01081.x.
  7. *Nakamura H, Wakita S, Suganami A, Tamura Y, Hanada K, Murayama T (2010) Modulation of the activity of cytosolic phospholipase A2alpha (cPLA2alpha) by cellular sphingolipids and inhibition of cPLA2alpha by sphingomyelin, J Lipid Res, 51, 720-728. doi: 10.1194/jlr.M002428.
  8. Kudo N, Kumagai K, Matsubara R, Kobayashi S, Hanada K, Wakatsuki S, *Kato R (2010) Crystal structures of the CERT START domain with inhibitors provide insights into the mechanism of ceramide transfer, J Mol Biol, 396, 245-251. doi: 10.1016/j.jmb.2009.12.029.
  9. *Hanada K (2010) Intracellular trafficking of ceramide by ceramide transfer protein, Proc Jpn Acad Ser B Phys Biol Sci, 86, 426-437. doi: 10.2183/pjab.86.426. (Open access: https://www.jstage.jst.go.jp/article/pjab/86/4/86_4_426/_article)

2009年

  1. Tomishige N, Kumagai K, Kusuda J, Nishijima M, *Hanada K (2009) Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin, Mol Biol Cell, 20, 348-357. doi: 10.1091/mbc.E08-07-0669. (Open access: http://www.molbiolcell.org/content/20/1/348.long)
  2. *Tanida I, Fukasawa M, Ueno T, Kominami E, Wakita T, Hanada K (2009) Knockdown of autophagy-related gene decreases the production of infectious hepatitis C virus particles, Autophagy, 5, 937-945.
  3. Nitahara-Kasahara Y, *Fukasawa M, Shinkai-Ouchi F, Sato S, Suzuki T, Murakami K, Wakita T, Hanada K, Miyamura T, Nishijima M (2009) Cellular vimentin content regulates the protein level of hepatitis C virus core protein and the hepatitis C virus production in cultured cells, Virology, 383, 319-327. doi: 10.1016/j.virol.2008.10.009.
  4. Momin AA, Park H, Allegood JC, Leipelt M, Kelly SL, *Merrill AH, Jr., Hanada K (2009) Characterization of mutant serine palmitoyltransferase 1 in LY-B cells, Lipids, 44, 725-732. doi: 10.1007/s11745-009-3316-4.
  5. *Hanada K, Kumagai K, Tomishige N, Yamaji T (2009) CERT-mediated trafficking of ceramide, Biochim Biophys Acta, 1791, 684-691. doi: 10.1016/j.bbalip.2009.01.006.(本論文が掲載された号の表紙に我々の研究結果が採用された)

2008年

  1. Yamaji T, Kumagai K, Tomishige N, *Hanada K (2008) Two sphingolipid transfer proteins, CERT and FAPP2: their roles in sphingolipid metabolism, IUBMB Life, 60, 511-518. doi: 10.1002/iub.83. (Open access: http://onlinelibrary.wiley.com/doi/10.1002/iub.83/pdf)
  2. Tsuda K, Furuta N, Inaba H, Kawai S, Hanada K, *Yoshimori T, Amano A (2008) Functional analysis of alpha5beta1 integrin and lipid rafts in invasion of epithelial cells by Porphyromonas gingivalis using fluorescent beads coated with bacterial membrane vesicles, Cell Struct Funct, 33, 123-132.
  3. *Tanida I, Yamaji T, Ueno T, Ishiura S, Kominami E, Hanada K (2008) Consideration about negative controls for LC3 and expression vectors for four colored fluorescent protein-LC3 negative controls, Autophagy, 4, 131-134.
  4. *Separovic D, Semaan L, Tarca AL, Awad Maitah MY, Hanada K, Bielawski J, Villani M, Luberto C (2008) Suppression of sphingomyelin synthase 1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage, Exp Cell Res, 314, 1860-1868. doi: 10.1016/j.yexcr.2008.02.008.
  5. Saito S, Matsui H, Kawano M, Kumagai K, Tomishige N, Hanada K, Echigo S, *Tamura S, *Kobayashi T (2008) Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes, J Biol Chem, 283, 6584-6593. doi: 10.1074/jbc.M707691200.
  6. Okemoto-Nakamura Y, Yamakawa Y, Hanada K, Tanaka K, Miura M, Tanida I, Nishijima M, *Hagiwara K (2008) Synthetic fibril peptide promotes clearance of scrapie prion protein by lysosomal degradation, Microbiol Immunol, 52, 357-365. doi: 10.1111/j.1348-0421.2008.00046.x.
  7. Okemoto K, Hanada K, Nishijima M, *Kawasaki K (2008) The preparation of a lipidic endotoxin affects its biological activities, Biol Pharm Bull, 31, 1952-1954.
  8. *Maehama T, Tanaka M, Nishina H, Murakami M, Kanaho Y, Hanada K (2008) RalA functions as an indispensable signal mediator for the nutrient-sensing system, J Biol Chem, 283, 35053-35059. doi: 10.1074/jbc.M805822200.
  9. Kudo N, Kumagai K, Tomishige N, Yamaji T, *Wakatsuki S, Nishijima M, *Hanada K, Kato R (2008) Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide, Proc Natl Acad Sci U S A, 105, 488-493. doi: 10.1073/pnas.0709191105. (Open access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206563/)
  10. *Haruna K, Suga Y, Muramatsu S, Taneda K, Mizuno Y, Ikeda S, Ueno T, Kominami E, Tanida I, Tanida I, Hanada K (2008) Differentiation-specific expression and localization of an autophagosomal marker protein (LC3) in human epidermal keratinocytes, J Dermatol Sci, 52, 213-215. doi: 10.1016/j.jdermsci.2008.07.005.
  11. Haberkant P, Schmitt O, Contreras FX, Thiele C, Hanada K, Sprong H, Reinhard C, *Wieland FT, *Brugger B (2008) Protein-sphingolipid interactions within cellular membranes, J Lipid Res, 49, 251-262. doi: 10.1194/jlr.D700023-JLR200.
  12. Giussani P, Colleoni T, Brioschi L, Bassi R, Hanada K, Tettamanti G, Riboni L, *Viani P (2008) Ceramide traffic in C6 glioma cells: evidence for CERT-dependent and independent transport from ER to the Golgi apparatus, Biochim Biophys Acta, 1781, 40-51. doi: 10.1016/j.bbalip.2007.11.002.
  13. Charruyer A, Bell SM, Kawano M, Douangpanya S, Yen TY, Macher BA, Kumagai K, Hanada K, Holleran WM, *Uchida Y (2008) Decreased ceramide transport protein (CERT) function alters sphingomyelin production following UVB irradiation, J Biol Chem, 283, 16682-16692. doi: 10.1074/jbc.M800799200.
  14. Aizaki H, Morikawa K, Fukasawa M, Hara H, Inoue Y, Tani H, Saito K, Nishijima M, Hanada K, Matsuura Y, Lai MM, Miyamura T, Wakita T, *Suzuki T (2008) Critical role of virion-associated cholesterol and sphingolipid in hepatitis C virus infection, J Virol, 82, 5715-5724. doi: 10.1128/JVI.02530-07.

2007年

  1. Shi L, Bielawski J, Mu J, Dong H, Teng C, Zhang J, Yang X, Tomishige N, Hanada K, Hannun YA, *Zuo J (2007) Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis, Cell Res, 17, 1030-1040. doi: 10.1038/cr.2007.100.
  2. *Separovic D, Hanada K, Maitah MY, Nagy B, Hang I, Tainsky MA, Kraniak JM, Bielawski J (2007) Sphingomyelin synthase 1 suppresses ceramide production and apoptosis post-photodamage, Biochem Biophys Res Commun, 358, 196-202. doi: 10.1016/j.bbrc.2007.04.095.
  3. Sano O, Kobayashi A, Nagao K, Kumagai K, Kioka N, Hanada K, *Ueda K, Matsuo M (2007) Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1, J Lipid Res, 48, 2377-2384. doi: 10.1194/jlr.M700139-JLR200.
  4. Nagao K, Takahashi K, Hanada K, Kioka N, Matsuo M, *Ueda K (2007) Enhanced apoA-I-dependent cholesterol efflux by ABCA1 from sphingomyelin-deficient Chinese hamster ovary cells, J Biol Chem, 282, 14868-14874. doi: 10.1074/jbc.M611230200.
  5. Kumagai K, Kawano M, Shinkai-Ouchi F, Nishijima M, *Hanada K (2007) Interorganelle trafficking of ceramide is regulated by phosphorylation-dependent cooperativity between the PH and START domains of CERT, J Biol Chem, 282, 17758-17766. doi: 10.1074/jbc.M702291200. (Open access: http://www.jbc.org/content/282/24/17758.long)
  6. *Hanada K, Kumagai K, Tomishige N, Kawano M (2007) CERT and intracellular trafficking of ceramide, Biochim Biophys Acta, 1771, 644-653. doi: 10.1016/j.bbalip.2007.01.009.

2006年

  1. Valeva A, Hellmann N, Walev I, Strand D, Plate M, Boukhallouk F, Brack A, Hanada K, Decker H, *Bhakdi S (2006) Evidence that clustered phosphocholine head groups serve as sites for binding and assembly of an oligomeric protein pore, J Biol Chem, 281, 26014-26021. doi: 10.1074/jbc.M601960200.
  2. *Separovic D, Wang S, Awad Maitah MY, Hanada K, Kessel D (2006) Ceramide response post-photodamage is absent after treatment with HA14-1, Biochem Biophys Res Commun, 345, 803-808. doi: 10.1016/j.bbrc.2006.04.131.
  3. Okemoto K, Kawasaki K, Hanada K, Miura M, *Nishijima M (2006) A potent adjuvant monophosphoryl lipid A triggers various immune responses, but not secretion of IL-1beta or activation of caspase-1, J Immunol, 176, 1203-1208.
  4. Kawano M, Kumagai K, Nishijima M, *Hanada K (2006) Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT, J Biol Chem, 281, 30279-30288. doi: 10.1074/jbc.M605032200. (Open access: http://www.jbc.org/content/281/40/30279.long)
  5. *Hanada K (2006) Discovery of the molecular machinery CERT for endoplasmic reticulum-to-Golgi trafficking of ceramide, Mol Cell Biochem, 286, 23-31. doi: 10.1007/s11010-005-9044-z.
  6. Grimmer S, Spilsberg B, *Hanada K, Sandvig K (2006) Depletion of sphingolipids facilitates endosome to Golgi transport of ricin, Traffic, 7, 1243-1253. 10.1111/j.1600-0854.2006.00456.x.
  7. *Fukasawa M, Tanaka Y, Sato S, Ono Y, Nitahara-Kasahara Y, Suzuki T, Miyamura T, Hanada K, Nishijima M (2006) Enhancement of de novo fatty acid biosynthesis in hepatic cell line Huh7 expressing hepatitis C virus core protein, Biol Pharm Bull, 29, 1958-1961.
  8. Cheng ZJ, Singh RD, Sharma DK, Holicky EL, Hanada K, Marks DL, *Pagano RE (2006) Distinct mechanisms of clathrin-independent endocytosis have unique sphingolipid requirements, Mol Biol Cell, 17, 3197-3210. doi: 10.1091/mbc.E05-12-1101.

2005年

  1. Tse SM, Mason D, Botelho RJ, Chiu B, Reyland M, Hanada K, Inman RD, *Grinstein S (2005) Accumulation of diacylglycerol in the Chlamydia inclusion vacuole: possible role in the inhibition of host cell apoptosis, J Biol Chem, 280, 25210-25215. doi: 10.1074/jbc.M501980200.
  2. Spilsberg B, Hanada K, *Sandvig K (2005) Diphtheria toxin translocation across cellular membranes is regulated by sphingolipids, Biochem Biophys Res Commun, 329, 465-473. doi: 10.1016/j.bbrc.2005.02.005.
  3. Kumagai K, Yasuda S, Okemoto K, Nishijima M, Kobayashi S, *Hanada K (2005) CERT mediates intermembrane transfer of various molecular species of ceramides, J Biol Chem, 280, 6488-6495. 10.1074/jbc.M409290200. (Open access: http://www.jbc.org/content/281/40/30279.long)
  4. Harikumar KG, Puri V, Singh RD, Hanada K, Pagano RE, *Miller LJ (2005) Differential effects of modification of membrane cholesterol and sphingolipids on the conformation, function, and trafficking of the G protein-coupled cholecystokinin receptor, J Biol Chem, 280, 2176-2185. 10.1074/jbc.M410385200.
  5. *Hanada K (2005) Sphingolipids in infectious diseases, Jpn J Infect Dis, 58, 131-148. (Open access: https://www0.niid.go.jp/JJID/58/131.pdf)
  6. Dolgachev V, Oberley LW, Huang TT, Kraniak JM, Tainsky MA, Hanada K, *Separovic D (2005) A role for manganese superoxide dismutase in apoptosis after photosensitization, Biochem Biophys Res Commun, 332, 411-417. doi: 10.1016/j.bbrc.2005.04.141.

2004年

  1. Sawamura N, Ko M, Yu W, Zou K, Hanada K, Suzuki T, Gong JS, Yanagisawa K, *Michikawa M (2004) Modulation of amyloid precursor protein cleavage by cellular sphingolipids, J Biol Chem, 279, 11984-11991. doi: 10.1074/jbc.M309832200.
  2. Miura Y, Gotoh E, Nara F, Nishijima M, *Hanada K (2004) Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases, FEBS Lett, 557, 288-292 doi:10.1016/S0014-5793(03)01523-0 (Open access: http://www.sciencedirect.com/science/article/pii/S0014579303015230) [Correction, (2004) 565, 207; doi:10.1016/j.febslet.2004.04.001; Open access: http://www.sciencedirect.com/science/article/pii/S0014579304003965]
  3. Dolgachev V, Farooqui MS, Kulaeva OI, Tainsky MA, Nagy B, Hanada K, *Separovic D (2004) De novo ceramide accumulation due to inhibition of its conversion to complex sphingolipids in apoptotic photosensitized cells, J Biol Chem, 279, 23238-23249. doi: 10.1074/jbc.M311974200.
  4. Carracedo A, Geelen MJ, Diez M, Hanada K, Guzman M, *Velasco G (2004) Ceramide sensitizes astrocytes to oxidative stress: protective role of cannabinoids, Biochem J, 380, 435-440. doi: 10.1042/bj20031714.

2003年

  1. Yasuda S, Nishijima M, *Hanada K (2003) Localization, topology, and function of the LCB1 subunit of serine palmitoyltransferase in mammalian cells, J Biol Chem, 278, 4176-4183. doi: 10.1074/jbc.M209602200. (Open access: http://www.jbc.org/content/278/6/4176.long)
  2. Nakamura Y, Matsubara R, Kitagawa H, *Kobayashi S, Kumagai K, Yasuda S, *Hanada K (2003) Stereoselective synthesis and structure-activity relationship of novel ceramide trafficking inhibitors. (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide and its analogues, J Med Chem, 46, 3688-3695. doi: 10.1021/jm0300779.
  3. Nakamura M, Mori Y, Okuyama K, Tanikawa K, Yasuda S, Hanada K, *Kobayashi S (2003) Chemistry and biology of khafrefungin. Large-scale synthesis, design, and structure-activity relationship of khafrefungin, an antifungal agent, Org Biomol Chem, 1, 3362-3376.
  4. *Hanada K, Nishijima M (2003) Purification of mammalian serine palmitoyltransferase, a hetero-subunit enzyme for sphingolipid biosynthesis, by affinity-peptide chromatography, Methods Mol Biol, 228, 163-174. doi: 10.1385/1-59259-400-X:163.
  5. *Hanada K, Kumagai K, Yasuda S, Miura Y, Kawano M, Fukasawa M, Nishijima M (2003) Molecular machinery for non-vesicular trafficking of ceramide, Nature, 426, 803-809. doi: 10.1038/nature02188.
  6. *Hanada K (2003) Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism, Biochim Biophys Acta, 1632, 16-30. doi:10.1016/S1388-1981(03)00059-3.
  7. Dolgachev V, Nagy B, Taffe B, Hanada K, *Separovic D (2003) Reactive oxygen species generation is independent of de novo sphingolipids in apoptotic photosensitized cells, Exp Cell Res, 288, 425-436.

2002年

  1. Wispriyono B, Schmelz E, Pelayo H, Hanada K, *Separovic D (2002) A role for the de novo sphingolipids in apoptosis of photosensitized cells, Exp Cell Res, 279, 153-165.
  2. *Lafont F, Tran Van Nhieu G, Hanada K, Sansonetti P, van der Goot FG (2002) Initial steps of Shigella infection depend on the cholesterol/sphingolipid raft-mediated CD44-IpaB interaction, EMBO J, 21, 4449-4457.
  3. *Hanada K, Palacpac NM, Magistrado PA, Kurokawa K, Rai G, Sakata D, Hara T, Horii T, Nishijima M, *Mitamura T (2002) Plasmodium falciparum phospholipase C hydrolyzing sphingomyelin and lysocholinephospholipids is a possible target for malaria chemotherapy, J Exp Med, 195, 23-34. (Open access: http://jem.rupress.org/content/195/1/23.long)
  4. Bejaoui K, Uchida Y, Yasuda S, Ho M, Nishijima M, Brown RH, Jr., Holleran WM, *Hanada K (2002) Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis, J Clin Invest, 110, 1301-1308. 10.1172/JCI16450. (Open access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151618/)

2001年

  1. Yasuda S, Kitagawa H, Ueno M, Ishitani H, Fukasawa M, Nishijima M, Kobayashi S, *Hanada K (2001) A novel inhibitor of ceramide trafficking from the endoplasmic reticulum to the site of sphingomyelin synthesis, J Biol Chem, 276, 43994-44002. doi: 10.1074/jbc.M104884200 (Open access: http://www.jbc.org/content/276/47/43994.long) [Errantum, (2013) 288, 24162; doi: 10.1074/jbc.A113.104884; Open access: http://www.jbc.org/content/288/33/24162.short]
  2. Miura Y, Hanada K, *Jones TL (2001) G(s) signaling is intact after disruption of lipid rafts, Biochemistry, 40, 15418-15423.
  3. *Kobayashi S, Mori K, Wakabayashi T, Yasuda S, Hanada K (2001) Convergent total synthesis of khafrefungin and its inhibitory activity of fungal sphingolipid syntheses, J Org Chem, 66, 5580-5584.
  4. Chatterjee S, Smith ER, Hanada K, Stevens VL, *Mayor S (2001) GPI anchoring leads to sphingolipid-dependent retention of endocytosed proteins in the recycling endosomal compartment, EMBO J, 20, 1583-1592. doi: 10.1093/emboj/20.7.1583.
  5. Ueno, M, Kitagawa H, , Ishitani H, Yasuda S, Hanada K, *Kobayashi S (2001) Catalytic enantioselective synthesis of a novel inhibitor of ceramide trafficking, (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide (HPA-12), Tetrahedron Lett. 42, 7863-7865.

2000年

  1. van Ooij C, Kalman L, van I, Nishijima M, Hanada K, Mostov K, *Engel JN (2000) Host cell-derived sphingolipids are required for the intracellular growth of Chlamydia trachomatis, Cell Microbiol, 2, 627-637.
  2. *Mitamura T, Hanada K, Ko-Mitamura EP, Nishijima M, Horii T (2000) Serum factors governing intraerythrocytic development and cell cycle progression of Plasmodium falciparum, Parasitol Int, 49, 219-229.
  3. *Hanada K, Nishijima M, Fujita T, Kobayashi S (2000) Specificity of inhibitors of serine palmitoyltransferase (SPT), a key enzyme in sphingolipid biosynthesis, in intact cells. A novel evaluation system using an SPT-defective mammalian cell mutant, Biochem Pharmacol, 59, 1211-1216.
  4. *Hanada K, Nishijima M (2000) Selection of mammalian cell mutants in sphingolipid biosynthesis, Methods Enzymol, 312, 304-317.
  5. *Hanada K, Mitamura T, Fukasawa M, Magistrado PA, Horii T, Nishijima M (2000) Neutral sphingomyelinase activity dependent on Mg2+ and anionic phospholipids in the intraerythrocytic malaria parasite Plasmodium falciparum, Biochem J, 346, 671-677. (Open access: http://www.biochemj.org/bj/346/0671/bj3460671.htm)
  6. *Hanada K, Hara T, Nishijima M (2000) D-Serine inhibits serine palmitoyltransferase, the enzyme catalyzing the initial step of sphingolipid biosynthesis, FEBS Lett, 474, 63-65. (Open access: http://www.sciencedirect.com/science/article/pii/S0014579300015799)
  7. *Hanada K, Hara T, Nishijima M (2000) Purification of the serine palmitoyltransferase complex responsible for sphingoid base synthesis by using affinity peptide chromatography techniques, J Biol Chem, 275, 8409-8415. (Open access: http://www.jbc.org/content/275/12/8409.long)
  8. Funakoshi T, Yasuda S, Fukasawa M, Nishijima M, *Hanada K (2000) Reconstitution of ATP- and cytosol-dependent transport of de novo synthesized ceramide to the site of sphingomyelin synthesis in semi-intact cells, J Biol Chem, 275, 29938-29945. 10.1074/jbc.M004470200. (Open access: http://www.jbc.org/content/275/39/29938.long)
  9. Fukasawa M, Nishijima M, Itabe H, Takano T, *Hanada K (2000) Reduction of sphingomyelin level without accumulation of ceramide in Chinese hamster ovary cells affects detergent-resistant membrane domains and enhances cellular cholesterol efflux to methyl-beta -cyclodextrin, J Biol Chem, 275, 34028-34034. doi: 10.1074/jbc.M005151200. (Open access: http://www.jbc.org/content/275/44/34028.long)

1999年以前

  1. Fukasawa M, Nishijima M, *Hanada K (1999) Genetic evidence for ATP-dependent endoplasmic reticulum-to-Golgi apparatus trafficking of ceramide for sphingomyelin synthesis in Chinese hamster ovary cells, J Cell Biol, 144, 673-685. (Open access: http://jcb.rupress.org/content/144/4/673.long)
  2. Suzuki T, Suzuki Y, Hanada K, Hashimoto A, Redpath JL, Stanbridge EJ, Nishijima M, *Kitagawa T (1998) Reduction of caveolin-1 expression in tumorigenic human cell hybrids, J Biochem, 124, 383-388.
  3. *Kobayashi S, Furuta T, Hayashi T, Nishijima M, Hanada K (1998) Catalytic asymmetric syntheses of antifungal sphingofungins and their biological activity as potent inhibitors of serine palmitoyltransferase (SPT), J Am Chem Soc, 200, 908-919.
  4. *Hanada K, Hara T, Fukasawa M, Yamaji A, Umeda M, Nishijima M (1998) Mammalian cell mutants resistant to a sphingomyelin-directed cytolysin. Genetic and biochemical evidence for complex formation of the LCB1 protein with the LCB2 protein for serine palmitoyltransferase, J Biol Chem, 273, 33787-33794. (Open access: http://www.jbc.org/content/273/50/33787.long)
  5. Yamamoto H, Hanada K, *Nishijima M (1997) Involvement of diacylglycerol production in activation of nuclear factor kappaB by a CD14-mediated lipopolysaccharide stimulus, Biochem J, 325 ( Pt 1), 223-228.
  6. Yamamoto H, Hanada K, Kawasaki K, *Nishijima M (1997) Inhibitory effect on curcumin on mammalian phospholipase D activity, FEBS Lett, 417, 196-198.
  7. *Hanada K, Hara T, Nishijima M, Kuge O, Dickson RC, Nagiec MM (1997) A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis, J Biol Chem, 272, 32108-32114. (Open access: http://www.jbc.org/content/272/51/32108.long)
  8. Fukasawa M, Sekine F, Miura M, Nishijima M, *Hanada K (1997) Involvement of heparan sulfate proteoglycans in the binding step for phagocytosis of latex beads by Chinese hamster ovary cells, Exp Cell Res, 230, 154-162. doi: 10.1006/excr.1996.3403.
  9. Hanada K, *Pagano RE (1995) A Chinese hamster ovary cell mutant defective in the non-endocytic uptake of fluorescent analogs of phosphatidylserine: isolation using a cytosol acidification protocol, J. Cell Biol., 128, 793-804.
  10. *Hanada K, Nishijima M, Akamatsu Y, Pagano RE (1995) Both sphingolipids and cholesterol participate in the detergent insolubility of alkaline phosphatase, a glycosylphosphatidylinositol-anchored protein, in mammalian membranes, J Biol Chem, 270, 6254-6260. (Open access: http://www.jbc.org/content/270/11/6254.long)
  11. *Hanada K, Izawa K, Nishijima M, Akamatsu Y (1993) Sphingolipid deficiency induces hypersensitivity of CD14, a glycosyl phosphatidylinositol-anchored protein, to phosphatidylinositol-specific phospholipase C, J Biol Chem, 268, 13820-13823. (Open access: http://www.jbc.org/content/268/19/13820.long)
  12. Hanada K, Yoshida T, Yamato I, *Anraku Y (1992) Sodium ion and proline binding sites in the Na+/proline symport carrier of Escherichia coli, Biochim Biophys Acta, 1105, 61-66.
  13. *Hanada K, Nishijima M, Kiso M, Hasegawa A, Fujita S, Ogawa T, Akamatsu Y (1992) Sphingolipids are essential for the growth of Chinese hamster ovary cells. Restoration of the growth of a mutant defective in sphingoid base biosynthesis by exogenous sphingolipids, J Biol Chem, 267, 23527-23533. (Open access: http://www.jbc.org/content/267/33/23527.long)
  14. *Hanada K, Horii M, Akamatsu Y (1991) Functional reconstitution of sphingomyelin synthase in Chinese hamster ovary cell membranes, Biochim Biophys Acta, 1086, 151-156.
  15. *Hanada K, Nishijima M, Akamatsu Y (1990) A temperature-sensitive mammalian cell mutant with thermolabile serine palmitoyltransferase for the sphingolipid biosynthesis, J Biol Chem, 265, 22137-22142. (Open access: http://www.jbc.org/content/265/36/22137.long)
  16. Komeiji Y, Hanada K, Yamato I, *Anraku Y (1989) Orientation of the carboxyl terminus of the Na+/proline symport carrier in Escherichia coli, FEBS Lett, 256, 135-138.
  17. Hanada K, Yamato I, *Anraku Y (1988) Solubilization and reconstitution of proline carrier in Escherichia coli; quantitative analysis and optimal conditions, Biochim Biophys Acta, 939, 282-288.
  18. Hanada K, Yamato I, *Anraku Y (1988) Purification and reconstitution of Escherichia coli proline carrier using a site specifically cleavable fusion protein, J Biol Chem, 263, 7181-7185. (Open access: http://www.jbc.org/content/263/15/7181.long)
  19. Hanada K, Yamato I, *Anraku Y (1987) Construction and properties of bifunctionally active membrane-bound fusion proteins. Escherichia coli proline carrier linked with beta-galactosidase, J Biol Chem, 262, 14100-14104. (Open access: http://www.jbc.org/content/262/29/14100.long)
  20. Hanada K, Yamato I, *Anraku Y (1985) Identification of proline carrier in Escherichia coli K-12, FEBS Lett, 191, 278-282.

 

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花田業績リスト                                                                          2016.8.15.更新

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2016

*Hanada K, and Sugiki T (2016): In vitro assay to extract specific lipid types from phospholipid membranes using lipid-transfer proteins: a lesson from the ceramide transport protein CERT, Neuromethods, in press.

Hernández-Tiedra S, Fabrias G, Salanueva IJ, Casas J, Dávila D, Montes RL, Antón Z, García-Taboada E, Salazar M, Lorente M, Nylandsted J, Armstrong J, López-Valero I, McKee CS, García-López R, Serrano A, Abad JL, Hanada K, Goñi FM, Guzmán M, Lovat P, Jäättelä M, Alonso A, and *Velasco G (2016) Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization, Autophagy, in press.

Shirasago Y, Shimizu Y, Tanida I, Suzuki T, Suzuki R, Sugiyama K, Wakita T, Hanada K, Yagi K, Kondoh M, and *Fukasawa M (2016) Occludin-knockout human hepatic Huh7.5.1-8-derived cells are completely resistant to hepatitis C virus infection, Biol Pharm Bull, 39, 839–848. doi: 10.1248/bpb.b15-01023

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