国立感染症研究所

花田業績リスト 　　　　　　　　　                                             2023.1.30.更新

・英文論文のみ記載（断りのない限り査読有）

・各論文の責任著者（corresponding author）には名前の左肩に*印をつけた。
・各論文のDigital Object Identifier (DOI)もわかる範囲で加えた。
・自身が責任著者の論文でOpen access（誰でもネットで全文ダウンロード可能）なものはURLを記載した。
・Google Scholarで提示された総引用数=12,621、h-index= 62; i10-Index=147 （2023.1.30.時点）

2023年

1. *Someya K, Okemoto-Nakamura Y, Kurata T, Saito N, Itamochi M, Otsuki N, Hanada K, Takeda M (2023) Establishment of Measles virus receptor-expressing Vero cells lacking functional poliovirus receptors, Microbiol Immunol, in press. doi: 10.1111/1348-0421.13047

2022年

1. *Sugiki T, Lee Y-H, Alsanousi N, Murata K; Kawamura I, Fujiwara T, Hanada K, *Kojima C (2022) A hybrid strategy combining solution NMR spectroscopy and isothermal titration calorimetry to characterize protein-nanodisc interaction, Anal Biochem, 639, article 114521. (T.S. & Y.-H. L. are co-first authors) Open access: https://doi.org/10.1016/j.ab.2021.11452
2. *Hanada K, Sakai S, Kumagai K (2022) Natural ligand-mimetic and nonmimetic inhibitors of the ceramide transport protein CERT, Int J Mol Sci, 23, article 2098. (invited review article) Open access: https://doi.org/10.3390/ijms23042098
3. Konishi K, Yamaji T, Sakuma C, Kasai F, Endo T, Kohara A, *Hanada K, *Osada N (2022) Whole-genome sequencing of Vero E6 (VERO C1008) and comparative analysis of four Vero cell sublines, Front Genetics, 13. article 801382. Open access: https://www.frontiersin.org/articles/10.3389/fgene.2022.801382/full
4. Fujita J, Taniguchi M, Hashizume C, Ueda Y, Sakai S, Kondo T, Hashimoto-Nishimura M, Hanada K, Kosaka T, *Okazaki T (2022) Nuclear ceramide is associated with ATM activation in the neocarzinostatin-induced apoptosis of lymphoblastoid cells, Mol Pharmacol, 101, 322-333. Doi: 10.1124/molpharm.121.000379
5. Shimasaki K, *Kumagai K, Sakai S, Yamaji T, *Hanada K (2022) Hyperosmotic stress induces phosphorylation of CERT and enhances its tethering throughout the endoplasmic reticulum, Int J Mol Sci, 23, article 4025. Open access: https://doi.org/10.3390/ijms23074025
6. *Konan K, Ogbamikael SA, Yager E, Yamaji T, Cerone J, Monaco-Brown M, Barroso M, Hanada K (2022) Modulation of Zika virus replication via glucosylceramide synthase and glycosphingolipids, Virology, 572, 17-27. Doi: 10.1016/j.virol.2022.03.014
7. *Hanada K (2022) Dysregulation of a lipid transfer protein linked to brain disorders, LIPID NEWS, ASBMB TODAY, April 12, 2022. Open access: https://www.asbmb.org/asbmb-today/science/041222/dysregulation-of-a-lipid-transfer-protein-linked-t (invited news article, non-peer-reviewed)
8. Kobayashi J, *Arita M, Sakai S, Kojima H, Senda M, Senda T, Hanada K, *Kato R (2022) Ligand recognition by the lipid transfer domain of human OSBP is important for enterovirus replication, ACS Infect Dis, 8, 1161–1170. Doi:10.1021/acsinfecdis.2c00108
9. Goto A, Sakai S, Mizuike A, Yamaji T, *Hanada K (2022) Compartmentalization of casein kinase 1 γ CSNK1G controls the intracellular trafficking of ceramide, iScience, 15, article 104624. Open access: https://doi.org/10.1016/j.isci.2022.104624.
10. Goto A, Egawa D, *Tomishige N, Yamaji T, Kumagai K, *Hanada K (2022) Involvement of a cluster of basic amino acids in phosphorylation-dependent functional repression of the ceramide transport protein CERT, Int J Mol Sci, 23, article 8576. (A.G. and D.E. are co-first authors) Open access: https://doi.org/10.3390/ijms23158576
11. *Saito K, kShimasaki K, Fukasawa M, Suzuki R, Okemoto-Nakamura Y, Katoh K, Takasaki T, Hanada K (2022) Establishment of Vero cell lines persistently harboring a yellow fever virus 17D subgenomic replicon, Virus Res, 322, article 198935. doi: 10.1016/j.virusres.2022.198935
12. *Mori Y, Sakata M, Sakai S, Okamoto T, Nakatsu Y, Taguwa S, Otsuki N, Maeda Y, Hanada K, Matsuura Y, Takeda M (2022) Membrane sphingomyelin in host cells is essential for nucleocapsid penetration into the cytoplasm after hemifusion during rubella virus entry, mBio, 13, e01698-22. Open access: https://doi.org/10.1128/mbio.01698-22
13. Shirasago Y, Fukazawa H, Nagase S, Shimizu Y, Wakita T, Suzuki T, Tani H, Kondoh M, Kuroda T, Yasuda S, Sato Y, Hanada K, *Fukasawa M (2022) A single mutation in the E2 glycoprotein of hepatitis C virus broadens the claudin specificity for its infection, Sci Rep, 12, article 20243. Open access: https://doi.org/10.1038/s41598-022-23824-3
14. *Kumagai K, Sakai S, Ueno M, Kataoka, Kobayashi S, *Hanada K (2022) Chlamydial infection-dependent synthesis of sphingomyelin as a novel anti-chlamydial target of ceramide-mimetic compounds, Int J Mol Sci, 23, article 14697. Open access: https://doi.org/10.3390/ijms232314697.

（2021年までの論文業績に関しては下の「・次へ>>」をクリックして下さい）

細胞化学部長から

花田の研究テーマなど

1. 私の志向する生化学、細胞生物学、そして体細胞遺伝学
2. スフィンゴ脂質について

III. 哺乳動物細胞におけるセラミド輸送に関する研究

1. 病原体による宿主脂質ハイジャック機序の解明と創薬への応用
2. 動物培養細胞に関する用語など
3. Vero細胞の物語　～その樹立からゲノム構造の決定、そして未来へ～

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