国立感染症研究所

花田研究業績（2022-）

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花田業績リスト 　　　　　　　　　                                             2023.8.30.更新

・英文論文のみ記載（断りのない限り査読有）

・各論文の責任著者（corresponding author）には名前の左肩に*印をつけた。
・各論文のDigital Object Identifier (DOI)もわかる範囲で加えた。
・Open access（誰でもネットで全文ダウンロード可能）なものはなるべくURLを記載した。
・Google Scholarで提示された総引用数=12,919、h-index= 64; i10-Index=146 （2023.8.30.時点）

2023年

  1. *Someya K, Okemoto-Nakamura Y, Kurata T, Saito N, Itamochi M, Otsuki N, Hanada K, Takeda M (2023) Establishment of Measles virus receptor-expressing Vero cells lacking functional poliovirus receptors, Microbiol Immunol, 67, 166-170. doi: 10.1111/1348-0421.13047
  2. *Goto A, Hanada K: Protocols for casein kinase 1γ3 CSNK1G3 gene knockout and recombinant gene expression in cultured mammalian cells, STAR Protocols, 4, article 102251, 2023. Open access: 10.1016/j.xpro.2023.102251
  3. Charlotte Gehin, Museer A. Lone, Winston Lee, Laura Capolupo, Sylvia Ho, Adekemi Adeyemi, Erica H. Gerkes, Alexander P.A. Stegmann, Estrella López-Martín, Eva Bermejo-Sánchez, Beatriz Martínez-Delgado, Christiane Zweier, Cornelia Kraus, Bernt Popp, Vincent Strehlow, Daniel Gräfe, Ina Knerr, Eppie Jones, Stefano Zamuner, Luciano A. Abriata, Vidya Kunnathully, Brandon E. Moeller, Anthony Vocat, Samuel Rommelaere, Jean-Philippe Bocquete, Evelyne Ruchti, Greta Limoni, Marine Van Campenhoudt, Samuel Bourgeat, Petra Henklein, Christian Gilissen, Bregje W. van Bon, Rolph Pfundt, Marjolein Willemsen, Jolanda Schieving, Emanuela Leonardi, Fiorenza Soli, Alessandra Murgia, Hui Guo, Qiumeng Zhang, Kun Xia, Christina R. Fagerberg, Christoph P. Beier, Martin J. Larsen, Irene Valenzuela, Paula Fernández-Álvarez, Shiyi Xiong, Robert Śmigiel, Vanesa López-González, Lluís Armengol, Manuela Morleo, Angelo Selicorni, Annalaura Torella, Moira Blyth, Nicola Cooper, Valerie Wilson, Renske Oegema, Yvan Herenger, Aurore Garde, Ange-Line Bruel, Frederic Tran Mau-Them, Alexis B.R. Maddocks, Jennifer M. Bain, Musadiq A. Bhat, Gregory Costain, Peter Kannu, Ashish Marwaha, Neena L. Champaigne, Michael J. Friez, Ellen B Richardson, Vykuntaraju K. Gowda, Varunvenkat M. Srinivasan, Yask Gupta, Tze Y. Lim, Simone Sanna-Cherchi, Bruno Lemaitre, Toshiyuki Yamaji , Kentaro Hanada, John E. Burke, Ana Marjia Jaksic, Brian D. McCabe, Paolo De Los Rios, *Thorsten Hornemann, *Giovanni D’Angelo, and *Vincenzo A. Gennarino: CERT mutations perturb human development by disrupting sphingolipid homeostasis, J Clin Invest, 133, e165019, 2023. (Gehin C, Lone MA, and Lee W are co-first authors) Open access: 10.1172/JCI165019
  4. Mizuike A, Sakai S, Katoh K, Yamaji T, *Hanada K: The C10orf76-PI4KB axis orchestrates CERT-mediated ceramide trafficking to the distal Golgi, J Cell Biol, 222, e202111069, 2023. Open access: 10.1083/jcb.202111069

 

2022年

  1. *Sugiki T, Lee Y-H, Alsanousi N, Murata K; Kawamura I, Fujiwara T, Hanada K, *Kojima C (2022) A hybrid strategy combining solution NMR spectroscopy and isothermal titration calorimetry to characterize protein-nanodisc interaction, Anal Biochem, 639, article 114521. (T.S. & Y.-H. L. are co-first authors) Open access: https://doi.org/10.1016/j.ab.2021.114521
  2. *Hanada K, Sakai S, Kumagai K (2022) Natural ligand-mimetic and nonmimetic inhibitors of the ceramide transport protein CERT, Int J Mol Sci, 23, article 2098. (invited review article) Open access: https://doi.org/10.3390/ijms23042098
  3. Konishi K, Yamaji T, Sakuma C, Kasai F, Endo T, Kohara A, *Hanada K, *Osada N (2022) Whole-genome sequencing of Vero E6 (VERO C1008) and comparative analysis of four Vero cell sublines, Front Genetics, 13, article 801382. Open access: https://www.frontiersin.org/articles/10.3389/fgene.2022.801382/full
  4. Fujita J, Taniguchi M, Hashizume C, Ueda Y, Sakai S, Kondo T, Hashimoto-Nishimura M, Hanada K, Kosaka T, *Okazaki T (2022) Nuclear ceramide is associated with ATM activation in the neocarzinostatin-induced apoptosis of lymphoblastoid cells, Mol Pharmacol, 101, 322-333. Doi: 10.1124/molpharm.121.000379
  5. Shimasaki K, *Kumagai K, Sakai S, Yamaji T, *Hanada K (2022) Hyperosmotic stress induces phosphorylation of CERT and enhances its tethering throughout the endoplasmic reticulum, Int J Mol Sci, 23, article 4025. Open access: https://doi.org/10.3390/ijms23074025
  6. *Konan K, Ogbamikael SA, Yager E, Yamaji T, Cerone J, Monaco-Brown M, Barroso M, Hanada K (2022) Modulation of Zika virus replication via glucosylceramide synthase and glycosphingolipids, Virology, 572, 17-27. Doi: 10.1016/j.virol.2022.03.014
  7. *Hanada K (2022) Dysregulation of a lipid transfer protein linked to brain disorders, LIPID NEWS, ASBMB TODAY, April 12, 2022. Open access: https://www.asbmb.org/asbmb-today/science/041222/dysregulation-of-a-lipid-transfer-protein-linked-t (invited news article, non-peer-reviewed)
  8. Kobayashi J, *Arita M, Sakai S, Kojima H, Senda M, Senda T, Hanada K, *Kato R (2022) Ligand recognition by the lipid transfer domain of human OSBP is important for enterovirus replication, ACS Infect Dis, 8, 1161–1170. Doi:10.1021/acsinfecdis.2c00108
  9. Goto A, Sakai S, Mizuike A, Yamaji T, *Hanada K (2022) Compartmentalization of casein kinase 1 γ CSNK1G controls the intracellular trafficking of ceramide, iScience, 15, article 104624. Open access: https://doi.org/10.1016/j.isci.2022.104624.
  10. Goto A, Egawa D, *Tomishige N, Yamaji T, Kumagai K, *Hanada K (2022) Involvement of a cluster of basic amino acids in phosphorylation-dependent functional repression of the ceramide transport protein CERT, Int J Mol Sci, 23, article 8576. (A.G. and D.E. are co-first authors) Open access: https://doi.org/10.3390/ijms23158576
  11. *Saito K, Shimasaki K, Fukasawa M, Suzuki R, Okemoto-Nakamura Y, Katoh K, Takasaki T, Hanada K (2022) Establishment of Vero cell lines persistently harboring a yellow fever virus 17D subgenomic replicon, Virus Res, 322, article 198935. doi: 10.1016/j.virusres.2022.198935
  12. *Mori Y, Sakata M, Sakai S, Okamoto T, Nakatsu Y, Taguwa S, Otsuki N, Maeda Y, Hanada K, Matsuura Y, Takeda M (2022) Membrane sphingomyelin in host cells is essential for nucleocapsid penetration into the cytoplasm after hemifusion during rubella virus entry, mBio, 13, e01698-22. Open access: https://doi.org/10.1128/mbio.01698-22
  13. Shirasago Y, Fukazawa H, Nagase S, Shimizu Y, Wakita T, Suzuki T, Tani H, Kondoh M, Kuroda T, Yasuda S, Sato Y, Hanada K, *Fukasawa M (2022) A single mutation in the E2 glycoprotein of hepatitis C virus broadens the claudin specificity for its infection, Sci Rep, 12, article 20243. Open access: https://doi.org/10.1038/s41598-022-23824-3
  14. *Kumagai K, Sakai S, Ueno M, Kataoka M, Kobayashi S, *Hanada K (2022) Chlamydial infection-dependent synthesis of sphingomyelin as a novel anti-chlamydial target of ceramide-mimetic compounds, Int J Mol Sci, 23, article 14697. Open access: https://doi.org/10.3390/ijms232314697.

 

（2021年までの論文業績に関しては下の「・次へ>>」をクリックして下さい）

 

花田の研究テーマなど

  1. 私の志向する生化学、細胞生物学、そして体細胞遺伝学
  2. スフィンゴ脂質について

III. 哺乳動物細胞におけるセラミド輸送に関する研究

  1. 病原体による宿主脂質ハイジャック機序の解明と創薬への応用
  2. 動物培養細胞に関する用語など
  3. Vero細胞の物語　～その樹立からゲノム構造の決定、そして未来へ～

 

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Copyright 1998 National Institute of Infectious Diseases, Japan

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