国立感染症研究所

花田研究業績（2018-）

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花田業績リスト 　　　　　　　　　                                             2020.5.29.更新

・英文論文のみ記載（断りのない限り査読有）

・各論文の責任著者（corresponding author）には名前の左肩に*印をつけた。
・各論文のDigital Object Identifier (DOI)もわかる範囲で加えた。PubMed検索の際に、copy/pasteで当該DOI番号を入力すれば論文の要旨Abstractにすぐにたどり着く。
・自身が責任著者の論文でOpen access（誰でもネットで全文ダウンロード可能）なものはURLを記載した。
・ScopusデータベースをもとにMendeleyプログラムで提示された総引用数=6516、h-index = 46 （2020.5.29.時点）

2020年

  1. Tachida Y, Kumagai K, Sakai S, Ando S, *Yamaji T, and *Hanada K: Chlamydia trachomatis-infected human cells convert ceramide to sphingomyelin without sphingomyelin synthases 1 and 2. FEBS Let, 594, 519-529. doi.org/10.1002/1873-3468.13632
  2.   *Hanada K (2020) Organelle contacts: sub-organelle zones to facilitate rapid and accurate inter-organelle trafficking of lipids.Traffic, 21, 189-196. doi.org/10.1111/tra.12716  (invited commentary)
  3. Ueno M, Miyoshi N, Hanada K, and *Kobayashi S (2020) Three-component, one-pot tandem Sonogashira/Suzuki–Miyaura coupling reactions for the synthesis of a library of ceramide-transport protein inhibitors designed in silico, Asia J Org Chem, 9, 267-273. DOI: 10.1002/ajoc.201900689
  4. *Saito K, Fukasawa M, Shirasago Y, Suzuki R, Osada N, Yamaji T, Wakita T, Konishi E, and Hanada K (2020) Comparative characterization of flavivirus production in two cell lines: Human hepatoma-derived Huh7.5.1-8 and African green monkey kidney-derived Vero. PLoS One, 15, e0232274. https://doi.org/10.1371/journal.pone.0232274
  5.  Morimoto K, Suzuki N, Tanida I, Kakuta S, Furuta Y, Uchiyama Y, Hanada K, Suzuki Y, *Yamaj T (2020) Blood group P1 antigen-bearing glycoproteins are functional but less efficient receptors of Shiga toxin than conventional glycolipid-based receptors, J Biol Chem, in press.

 2019年

  1. *Yamaji T, Sekizuka T, Tachida Y, Sakuma C, Kuroda M, and Hanada K (2019) A CRISPR screen identifies LAPTM4A and TM9SF proteins as glycolipid-regulating factors, iScience, 11, 409-424. doi.org/10.1016/j.isci.2018.12.039.
  2. Nakao N, Ueno M, Sakai S, Egawa D, Hanzawa H, Kawasaki S, Kumagai K, Suzuki M, *Kobayashi S, and *Hanada K (2019) Natural ligand-nonmimetic inhibitors to the lipid transfer protein CERT, Comms Chem, 2, article 20.doi: 10.1038/s42004-019-0118-3 (N.N., M.U., and S.S. are co-first authors) (open access: https://www.nature.com/articles/s42004-019-0118-3)
  3. Shirasago Y, Inamori Y, Suzuki T, Tanida I, Suzuki T, Sugiyama K, Wakita T, Hanada K, and *Fukasawa M (2019) Inhibition mechanisms of hepatitis C virus infection by caffeic acid and tannic acid, Biol Pharm Bull, 42, 770. doi:10.1248/bpb.b18-00970 (a Highlighted paper selected by Editor-in-Chief).
  4. Shimizu Y, Shirasago Y, Suzuki T, Hata T, Kondoh M, Hanada K, Yagi K, and *Fukasawa M (2019) Characterization of monoclonal antibodies recognizing each extracellular loop domain of occluding, J Biochem, 166, 297-308. doi: 10.1093/jb/mvz037
  5. *Yamaji T, Hanamatsu H, Sekizuka T, Kuroda M, Ohnishi M,Furukawa J, Yahiro K,, and Hanada K (2019) A CRISPR screen using subtilase cytotoxin identifies SLC39A9 as a glycan-regulating factor, iScience, 15, 407-420. doi: 10.1016/j.isci.2019.05.005
  6.   *Kumagai K, and *Hanada K (2019) Structure, functions, and regulation of CERT, a lipid-transfer protein for the delivery of ceramide at the ER-Golgi membrane contact sites, FEBS Let, 593, 2366-2377. https://doi.org/10.1002/1873-3468.13511 (invited review) 
  7. *Osawa T, *Shimamura T, Saito K, Hasegawa Y, Ishii N, Nishida M, Kondo A, Anwar M, Tsuchida R,Hino S, Sakamoto A, Igarashi K, Saitoh K, Kato K, Endo K, Yamano S, Kanki Y, Matsumura Y, Minami T, Tanaka T, Anai M, Wada Y, Wanibuchi H, Hayashi M, Hamada A, Yoshida M, Yachida S, Nakao M, Sakai J, Aburatani H, Shibuya M, Hanada K, Miyano S, *Soga T, and *Kodama T (2019) Phosphoethanolamine accumulation protects cancer cells under glutamine starvation through downregulation of PCYT2. Cell Rep, 29, 89-103. doi.org/10.1016/j.celrep.2019.08.087
  8. *Okemoto-Nakamura Y, Tanida I, Yamaji T, *Hanada K, and Hagiwara K (2019) A PRNP-disrupted human neuroblastoma cell line and its stable transformants expressing human prion variants. BPB Rep, 2, 73-79. (Open access: https://www3.e-kenkyu.com/bpb-reports-online-journal/uploads/manuscript/file/38/2_73.pdf).

2018年

  1. Sakuma C, Sekizuka T, Kuroda M, Kasai F, Saito K, Ikeda M, Yamaji T, *Osada N, and *Hanada K (2018) Novel endogenous simian retroviral integrations in Vero cells: implications for quality control of a human vaccine cell substrate, Sci Rep, 8, 644. (C.S. and T.S. are co-first authors. N.O. and K.H. are co-correspondence) doi: 10.1038/s41598-017-18934-2. (Open access: https://www.nature.com/articles/s41598-017-18934-2)
  2. Shimasaki K, Watanabe-Takahash M, Umeda M, Funamoto S, Saito Y, Noguchi N, Kumagai K, Hanada K, Tsukahara F, Maru Y, Shibata N, Naito M, and *Nishikawa K (2018) Pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy, Genes Cells, 23, 22-34. doi: 10.1111/gtc.12544.
  3. Otsuki N, Sakata M, Saito K, Okamoto K, Mori Y, *Hanada K, and *Takeda M (2018)  Both sphingomyelin and cholesterol in the host cell membrane are essential for Rubella virus entry. J Virol, 92, e01130-17. doi: 10.1128/JVI.01130-17.(selected as Spotlight)
  4. Shimizu Y, Shirasago Y, Kondoh M, Suzuki T, Wakita T, Hanada K, Yagi K, and *Fukasawa M (2018) Monoclonal antibodies against occludin completely prevented hepatitis C virus infection in a mouse model, J Virol, 92, e02258-17. doi:10.1128/JVI.02258-17. (selected as Spotlight)
  5. Sugiki T, Egawa D, Kumagai K, Kojima C, Fujiwara T, Takeuchi K, Shimada I, *Hanada K, and *Takahashi H (2018) Phosphoinositide binding by the PH domain in ceramide transfer protein (CERT) is inhibited by hyperphosphorylation of an adjacent serine-repeat motif, J Biol Chem, 293, 11206-11217. (T.S. and D.E. are co-first authors. K.H. and H.T. are co-correspondence) doi: 10.1074/jbc.RA118.002465.
  6. Ikeda M, Satomura K, Sekizuka T, Hanada K, Endo T, *Osada N (2018) Comprehensive phylogenomic analysis reveals a novel cluster of simian endogenous retroviral sequences in Colobinae monkeys, Am J Primatol, e22882. doi: 10.1002/ajp.22882.
  7. *Hanada K (2018) Lipid-transfer proteins rectify inter-organelle flux and accurately deliver lipids at membrane contact sites, J Lipid Res, 59, 1341-1366. doi:  org/10.1194/jlr.R085324 (Open access: http://www.jlr.org/content/59/8/1341.full.pdf+html) (invited review)
  8. *Saito K, Otsuki N, Takeda M, and Hanada K (2018) Liposome flotation assay for studying interactions between Rubella virus particles and lipid membranes, Bio-Protocol, 8(16), e2983.
  9. Shirasago Y, Fukazawa H, Aizaki H, Suzuki T, Suzuki T, Sugiyama K, Wakita T, Hanada K, Abe R, *Fukasawa M (2018) Thermostable hepatitis C virus JFH1-derived variant isolated by adaptation to Huh7.5.1 cells, J Gen Virol, 99(10), 1407-1417. doi: 10.1099/jgv.0.001117.
  10. *Kumagai K, Elwell CA, Andoh S, Engel JN, *Hanada K (2018) Both the N- and C- terminal regions of the Chlamydial inclusion protein D (IncD) are required for interaction with the pleckstrin homology domain of the ceramide transport protein CERT, Biochem Biophys Res Commun, 505(4), 1070-1076. doi: 10.1016/j.bbrc.2018.09.168.

（2017年までの論文業績に関しては下の「・次へ>>」をクリックして下さい）

細胞化学部長から

花田の研究テーマなど

  1. 私の志向する生化学、細胞生物学、そして体細胞遺伝学
  2. スフィンゴ脂質について

III. 哺乳動物細胞におけるセラミド輸送に関する研究

  1. 病原体による宿主脂質ハイジャック機序の解明と創薬への応用
  2. 動物培養細胞に関する用語など
  3. Vero細胞の物語　～その樹立からゲノム構造の決定、そして未来へ～

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