国立感染症研究所

研究情報　掲載記事一覧

クライオ電子顕微鏡解析とX線結晶構造解析による遺伝子型GI.4ノロウイルスのヒト型モノクローナル抗体結合部位の解明

2024/04/15

Structural analyses of the GI.4 norovirus by cryo-electron microscopy and X-ray crystallography revealing binding sites for human monoclonal antibod Read More

抗精神病薬ロキサピンは2Cタンパク質を標的とし、A型肝炎ウイルスの複製を阻害する

2024/03/26

Loxapine inhibits replication of hepatitis A virus in vitro and in vivo by targeting viral protein 2C

Mami Matsuda, Asuka Hirai-Yuki, Osamu Read More

肺炎球菌はエンドソーム膜上のシアル酸を刈り取ることで自身が産生する膜孔形成毒素の過剰な働きを抑制し、宿主細胞による排除から身を守る

2024/03/15

Pneumococcal sialidase promotes bacterial survival by fine-turning of pneumolysin-mediated membrane disruption

Sayaka Shizukuishi, Michinag Read More

エンテロウイルスA71の受容体SCARB2は細胞表面に無い

2024/02/22

Enterovirus A71 does not meet the uncoating receptor SCARB2 at the cell surface

Yorihiro Nishimura, Kei Sato, Yoshio Koyanagi, Takaji Wakit Read More

カルバペネム耐性腸内細菌目細菌のサーベイランス届出基準におけるメロペネム耐性の重要性：ナショナルサーベイランスの解析より

2024/02/21

The importance of meropenem resistance, rather than imipenem resistance, in defining carbapenem‑resistant Enterobacterales for public healt Read More

ハイスループットな中和抗体測定のためのJCポリオーマシュードウイルスの作製

2024/02/13

Generation of JC Polyoma Pseudovirus for High‐Throughput Measurement of Neutralizing Antibodies

Mami Matsuda, Tian‐Cheng Li, Akira Naka Read More

B型肝炎ウイルスと細胞側受容体の複合体構造の解明

2024/01/18

Structural basis of hepatitis B virus receptor binding

Asami J^#, Park JH^#, Nomura Y^#, Kobayashi C^{#Read More}

SARS-CoV-2感染性ウイルス排出期間と粘膜抗体応答の関係の解明

2024/01/11

Infectious virus shedding duration reflects secretory IgA antibody response latency after SARS-CoV-2 infection

Sho Miyamoto, Takara Nishiya Read More

2018年の全国データを基にしたプライマリケアにおける抗菌薬使用と菌血症を起こした大腸菌での薬剤耐性表現型の組み合わせに関する研究

2024/01/11

Antimicrobial use and combination of resistance phenotypes in bacteraemic Escherichia coli in primary care: a study based on Japanese national data Read More

院内病原体におけるプロファージ関連領域の薬剤耐性遺伝子と病原性関連遺伝子の分布

2024/01/11

Distribution of antimicrobial resistance and virulence genes within the prophage-associated regions in nosocomial pathogens

Kohei Kondo, Mi Read More

機械学習によって明らかとなったレプトスピラ症病原体の細胞接着と細胞上での運動の逆相関関係

2023/12/07

Machine learning-based motion tracking reveals an inverse correlation between adhesivity and surface motility of the leptospirosis spirochete

ポータブル機器による環境表面新型コロナウイルス迅速高感度検出法

2023/10/05

Rapid and sensitive on-site detection of SARS-CoV-2 RNA from environmental surfaces using portable laboratory devices

Kouichi Kitamura, Min Read More

BA.5オミクロン亜種への再感染に対する既感染とワクチン接種の防御効果：日本全国の集団ベースの研究

2023/09/25

Protective effect of previous infection and vaccination against reinfection with BA.5 Omicron subvariant: a nationwide population-based study in Jap Read More

膜融合型構造のインフルエンザヘマグルチニンに特異的な新規交差防御抗体の構造学的解析

2023/08/24

Structural basis for cross-group recognition of an influenza virus hemagglutinin antibody that targets postfusion stabilized epitope

Keisuk Read More

HTLV-1潜伏感染カニクイザルにおけるモノクローナル抗CD8抗体投与によるCD8陽性細胞枯渇によるHTLV-1増殖

2023/08/22

HTLV-1 Proliferation after CD8+ Cell Depletion by Monoclonal Anti-CD8 Antibody Administration in Latently HTLV-1-Infected Cynomolgus Macaques

アトバコン、メフロキンおよびモルヌピラビルの抗エムポックスウイルス活性と治療薬としての可能性

2023/07/28

Potential Anti-Mpox Virus Activity of Atovaquone, Mefloquine, and Molnupiravir, and Their Potential Use as Treatments

Akazawa D^a Read More

エムポックスウイルス創薬標的としてのイノシン一リン酸デヒドロゲナーゼ

2023/07/28

Identification of IMP Dehydrogenase as a Potential Target for Anti-Mpox Virus Agents

Hishiki T^#, Morita T^#, Akazawa D Read More

2c型および 2j型のP1細胞接着タンパク質を持つ肺炎マイコプラズマ株の増加

2023/06/20

Genotyping of Mycoplasma pneumoniae strains isolated in Japan during 2019 and 2020: spread of p1 gene type 2c and 2j variant strains

Kenri Read More

CD62LはSARS-CoV-2の中和エピトープを認識する記憶B細胞マーカーである

2023/06/16

CD62L expression marks SARS-CoV-2 memory B cell subset with preference for neutralizing epitopes

Taishi Onodera, Nicolas Sax, Takashi Sato, Read More

ゴルジ体遠位領域へのCERT依存的なセラミド輸送の場はC10orf76–PI4KBにより形成される

2023/05/25

The C10orf76–PI4KB axis orchestrates CERT-mediated ceramide trafficking to the distal Golgi

Mizuike A, Sakai S, Kat Read More

ヘリコバクター・スイス感染の血清学的検査法の開発

2023/05/25

Development of serological assays to identify Helicobacter suis and H. pylori infections.

Matsui H*, Rimbara E*, Suzu Read More

SARS-CoV-2ブレークスルー感染者血清抗体価を用いた適切なブースターワクチン接種間隔の推定

2023/04/28

Saturation time of exposure interval for cross-neutralization response to SARS-CoV-2: implications for vaccine dose intervalRead More

皮内接種によるセービン株由来不活化ポリオワクチンの用量節減効果

2023/04/17

Dose-sparing effect of Sabin-derived inactivated polio vaccine produced in Japan by intradermal injection device for rats

ポリオ環境水サーベイランスを活用した下水中エンテロウイルス及びSARS-CoV-2のモニタリング

2023/03/30

Monitoring Enteroviruses and SARS-CoV-2 in Wastewater Using the Polio Environmental Surveillance System in Japan

Kazuhiro Kitakawa , Kouich Read More

我が国における新型コロナワクチン導入後のCOVID-19の血清疫学調査

2023/02/02

National seroepidemiological study of COVID-19 after the initial rollout of vaccines: Before and at the peak of the Omicron-dominant period in Japan Read More

SARS-CoV-2ブレークスルー感染の免疫応答では上気道ウイルス増殖量とワクチン接種から感染までのインターバルが中和抗体の量と幅に影響する

2023/02/02

Non-Omicron breakthrough infection with higher viral load and longer vaccination-infection interval improves SARS-CoV-2 BA.4/5 Read More

アジアにおける超殺虫剤耐性デング熱媒介蚊の発見：ノックダウン抵抗性遺伝子の多重突然変異の脅威

2023/02/01

Discovery of super–insecticide-resistant dengue mosquitoes in Asia: Threats of concomitant knockdown resistance mutationsRead More

プロバイオティック大腸菌の膜小胞キメラを活用した莢膜保有病原体に対するワクチンプラットフォーム

2022/12/12

A highly immunogenic vaccine platform against encapsulated pathogens using chimeric probiotic Escherichia coli membrane vesicl Read More

黄熱ウイルスサブゲノミックレプリコンを持続的に保持するVero細胞の樹立

2022/12/07

Establishment of Vero cell lines persistently harboring a yellow fever virus 17D subgenomic replicon

Kyoko Saito, Kentaro Shimasaki, Masayo Read More

インターフェロン受容体欠損（Ifnar1-/-）マウスにおいて急性A型肝炎の終息後にマクロファージを欠乏させると、糞便中へのウイルス排出が再開する

2022/12/05

Macrophage depletion reactivates fecal virus shedding following resolution of acute hepatitis A in Ifnar1^-/- mice

Shiot Read More

ポリオウイルスの複製に必要とされるオキシステロール結合タンパク(OSBP)の領域の同定

2022/12/01

Essential domains of oxysterol-binding protein required for poliovirus replication

Minetaro Arita

Viruse Read More

風疹ウイルスの侵入過程におけるヘミフュージョン後のヌクレオキャプシドの細胞質への放出に、宿主膜のスフィンゴミエリンが必須である

2022/11/17

Membrane sphingomyelin in host cells is essential for nucleocapsid penetration into the cytoplasm after hemifusion during rubella virus entry

長期療養施設入所者の薬剤耐性グラム陰性菌の口腔と直腸への保菌状況と死亡との関連：多施設共同前向き観察研究

2022/10/25

Oral and Rectal Colonization by Antimicrobial-Resistant Gram-Negative Bacteria and Their Association with Death among Residents of Long-Term Care Fa Read More

マウス気道におけるSARS-CoV-2感染に不可欠なTMPRSS2の役割

2022/10/18

Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airways

Naoko Iwata-Yoshikawa¹, Masatoshi Kakizaki¹, Nozo Read More

抗ポリオウイルス中和抗体価を測定するためのハイスループット疑似ウイルス中和試験

2022/10/11

High-throughput analysis of anti-poliovirus neutralization antibody titre in human serum by the pseudovirus neutralization test

Minetaro Ar Read More

L-HBs抗原を用いた新規HBワクチンによるワクチンエスケープ変異株の感染中和

2022/09/12

Neutralization of Hepatitis B Virus with Vaccine-Escape Mutations by Hepatitis B Vaccine with Large-HBs Antigen.

Ayak Read More

デルタ株流行期・オミクロン株流行期における新型コロナワクチンの有効性評価

2022/08/04

COVID-19 vaccine effectiveness against symptomatic SARS-CoV-2 infection during Delta-dominant and Omicron-dominant periods in Japan: a multi-center Read More

新型コロナワクチンの接種意向と相関する社会・行動因子

2022/07/12

Social and Behavioral Factors Associated with Lack of Intent to Receive COVID-19 Vaccine, Japan

Takeshi Arashiro, Yuzo Arima, Ashley Stucky Read More

宿主のシアロ糖鎖は新型コロナウイルスの感染増殖に重要な役割を持つ

2022/06/21

Significant role of host sialylated glycans in the infection and spread of severe acute respiratory syndrome coronavirus 2

Saso W, Yamasaki Read More

B型肝炎ウイルス受容体である胆汁酸輸送体NTCPの立体構造決定

2022/06/21

Structural insights into the HBV receptor and bile acid transporter NTCP

Park H, Iwamoto M, Yun JH, Uchikubo-Kamo T, Son D, Jin Z, Yoshida Read More

B型およびD型肝炎ウイルスの細胞内侵入を阻害する真菌二次代謝産物

2022/06/21

Fungal Secondary Metabolite Exophillic Acid Selectively Inhibits the Entry of Hepatitis B and D Viruses

Kobayashi C, Watanabe Y, Oshima M, Read More

ヒトOSBPの脂質輸送ドメインによる基質の認識はエンテロウイルスの複製に重要である

2022/06/02

Ligand recognition by the lipid transfer domain of human OSBP is important for enterovirus replication

Jun Kobayashi, Minetaro Arita, Shota Read More

2回目ワクチン接種から感染までの日数がSARS-CoV-2オミクロン系統に対するブレークスルー感染者血清の交差中和活性を決定する

2022/05/28

Vaccination-infection interval determines cross-neutralization potency to SARS-CoV-2 Omicron after breakthrough infection by other variants

GagVif特異的CD8陽性T細胞反応を選択的に誘導するHIVワクチンの抗Env抗体非依存的な経直腸感染防御効果

2022/05/06

Env-independent protection of intrarectal SIV challenge by vaccine induction of Gag/Vif-specific CD8⁺ T cells but n Read More

SARS-CoV-2 mRNAワクチンの免疫原性と副反応にそれぞれ相関する免疫細胞ダイナミクス

2022/04/25

Distinct immune cell dynamics correlate with the immunogenicity and reactogenicity of SARS-CoV-2 mRNA vaccine

Takano T, Morikawa K, Adachi Read More

ウイルス様粒子を利用したDNAワクチンによるC型肝炎ウイルス中和抗体の誘導

2022/04/25

Induction of neutralizing antibodies against hepatitis C virus by a subviral particle-based DNA vaccine

Keigo Yato, Mami Matsuda, Noriyuki Read More

抗体誘導のためのウイルス表面膜蛋白抗原搭載センダイウイルス粒子ワクチンの開発

2022/04/07

Sendai virus particles carrying target virus glycoproteins for antibody induction

Ishii H, Nakamura-Hoshi M, Shu T, M Read More

経鼻ワクチン誘導CD8陽性T細胞反応の中和抗体非依存的な新型コロナウイルス感染制御効果

2022/03/15

Neutralizing-antibody-independent SARS-CoV-2 control correlated with intranasal-vaccine-induced CD8+ T cell responses

GI.9ノロウイルスが組織血液型抗原のルイスフコースを認識する仕組み

2022/03/02

Lewis fucose is a key moiety for the recognition of histo-blood group antigens by GI.9 norovirus, as revealed by structural analysis

Tomomi Read More

SARS-CoV-2オミクロン株を中和する記憶B細胞はBNT162b2 mRNAワクチンの2回接種により誘導される

2022/02/06

SARS-CoV-2 Omicron-neutralizing memory B-cells are elicited by two doses of BNT162b2 mRNA vaccine

Ryutaro Kotaki†, Yu Adachi†, Saya Mor Read More

ダサブビルはヒト腸管エンテロイドへのヒトノロウイルス感染を阻害する

2022/01/19

Dasabuvir Inhibits Human Norovirus Infection in Human Intestinal Enteroids

Tsuyoshi Hayashi, Kosuke Murakami, Junki Hirano, Yoshiki Fujii, Read More

SARS-CoV-2感染によるワクチン関連呼吸器疾患増強リスクを評価するための致死マウスモデル

2022/01/17

A lethal mouse model for evaluating vaccine-associated enhanced respiratory disease during SARS-CoV-2 infection

Iwata Read More

MARCH8は様々なウイルスエンベロープ糖蛋白質の細胞質領域リジン残基を標的とする

2022/01/14

MARCH8 targets cytoplasmic lysine residues of various viral envelope glycoproteins

Yanzhao Zhang, Seiya Ozono, Takuya Tada, Minoru Tobiume, Read More

アルミニウム塩アジュバント含有経鼻ワクチンは肺胞上皮細胞からのIL-33分泌を促し、2型免疫応答によるIgA抗体産生を促進させる

2021/12/07

Nasal alum-adjuvanted vaccine promotes IL-33 release from alveolar epithelial cells that elicits IgA production via type 2 immu Read More

HTLV-1感染で発現誘導される宿主因子M-Secは効率的なHTLV-1ウイルス感染に関与する

2021/12/03

M-Sec induced by HTLV-1 mediates an efficient viral transmission

Masateru Hiyoshi, Naofumi Takahashi, Youssef M. Eltalkhawy, Osamu Noyori, Read More

新型コロナウイルスの新規抗体はウイルスの弱点を攻撃することでSARS類縁ウイルスや変異株を幅広く中和する

2021/10/30

A SARS-CoV-2 Antibody Broadly Neutralizes SARS-related Coronaviruses and Variants by Coordinated Recognition of a Virus Vulnerable Site

Tai Read More

ハイスループットな中和試験法によるタイのフラビウイルス中和抗体の血清疫学調査：2012年のジカウイルスの蔓延状況

2021/10/25

Seroprevalence of Flavivirus Neutralizing Antibodies in Thailand by High-Throughput Neutralization Assay: Endemic Circulation of Zika Virus before 2 Read More

COVID-19パンデミックの薬剤耐性サーベイランスに与える影響

2021/10/01

Impact of the COVID-19 pandemic on the surveillance of antimicrobial resistance

Hirabayashi A, Kajihara T, Yahara K, Shibayama K, and Sugai Read More

高次エピスタシスおよび感染過程間の機能的カップリングが、宿主経路から独立するウイルス進化を促進する

2021/09/09

High-order epistasis and functional coupling of infection steps drive virus evolution toward independence from a host pathway

Minetaro Arit Read More

B型慢性肝炎の機能的治癒に関与するHBVコア領域I97L変異の機能解析

2021/08/10

Amino Acid Polymorphism in Hepatitis B Virus Associated with Functional Cure.

Takashi Honda, Norie Yamada, Asako Murayama, Masaaki Shiina, Read More

CD8陽性T細胞非存在下でのSARS-CoV-2複製制御の可能性

2021/07/22

Subacute SARS-CoV-2 replication can be controlled in the absence of CD8+ T cells in cynomolgus macaques.

Nomura T, Yamamoto H, Nishizawa M, Read More

COVID-19回復者での中和抗体が時間と共に成熟することにより、変異株への活性と交差性が向上する

2021/07/05

Temporal Maturation of Neutralizing Antibodies in COVID-19 Convalescent Individuals Improves Potency and Breadth to Circulating SARS-CoV-2 Variants< Read More

新型コロナウイルス感染培養系を用いた化合物スクリーニングによる新規抗ウイルス酸化ステロールの同定

2021/05/29

Identification of Anti-Severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Oxysterol Derivatives In Vitro

Ohashi H, Wang F, Stappenbeck F, Tsuchimoto Read More

抗新型コロナウイルス治療薬候補としてのネルフィナビルおよびセファランチンの同定とその併用療法による抗ウイルス効果

2021/05/29

Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment

Ohashi H, Watashi K*, Saso W, Shionoya K, Iwanami S, Hirokawa T Read More

メフロキンの新型コロナウイルスに対する強力な侵入阻害活性

2021/05/29

Mefloquine, a Potent anti-Severe Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2) drug as an entry inhibitor in vitro

Shionoya K, Yamasaki M, Iwanami S, I Read More

インターフェロンシグナルは、不全タンパク質反応を抑制し、B型肝炎ウイルス表面抗原を蓄積する肝細胞の細胞死を誘導する

2021/05/18

Interferon signaling suppresses the unfolded protein response and induces cell Read More

B型肝炎ウイルス受容体結合ドメイン内に存在する2箇所の重要な中和エピトープの同定

2021/04/22

Identification of two critical neutralizing epitopes in the receptor binding do Read More

TMPRSS2の生理的な活性阻害因子であるHAI-2は、新型コロナウイルスSARS-CoV-2の感染を抑制する

2021/04/09

The physiological TMPRSS2 inhibitor HAI-2 alleviates SARS-CoV-2 infection

ヒト胃からのヘリコバクター・スイスの培養に成功－ピロリ菌だけでなく、ヘリコバクター・スイスもヒト胃における病原細菌であることを証明－

2021/03/24

Isolation and characterization of Helicobacter suis from human stomach.

Rimbara E, Suzuki M, Matsui H, Nakamura M, Morimoto M, Sasakawa C, Masuda H, Nomura S, Osaki T, Nagata N, Shibayama K Read More

新型コロナウイルス感染症流行下では10歳未満の小児のライノウイルス感染リスクが上昇した

2021/03/17

Increased risk of rhinovirus infection in children during the coronavirus disea Read More

重症熱性血小板減少症候群患者に対するファビピラビルの治療効果と安全性を調べるための多施設単一アーム非無作為化試験

2021/02/24

A multicenter non-randomized, uncontrolled single arm trial for evaluation of t Read More

高度弱毒化ワクシニアウイルス株LC16m8を土台とした重症熱性血小板減少症候群ワクチン

2021/02/19

A highly attenuated vaccinia virus strain LC16m8-based vaccine for severe fever with thrombocytopenia syndrome.

Tomoki Yoshikawa, Satoshi Taniguch Read More

新型コロナウイルスD614Gスパイク変異はACE2結合親和性を高めることにより細胞内侵入効率を上昇させる

2021/02/09

SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding Read More

Mycobacterium abscessus complex （MABC）の亜種とマクロライド感受性を鑑別する新しいDNAクロマトグラフィー法

2021/01/21

A Novel DNA Chromatography Method to Discriminate Mycobacterium abscessus Subspecies and Macrolide Susceptibility.

Mitsunori Yoshida, Sotaro Sano, Jung-Yien Chien, Hanako Fukano, Masato Suz Read More

感染性の増加が懸念されるSARS-CoV-2新規変異株VOC-202012/01の分離に成功

2021/01/04

国立感染症研究所において、空港検疫により確認された新型コロナウイルス感染症の患者等の検体を用いてウイルス分離試験 Read More

下水沈殿物を用いた効率の良い新型コロナウイルスRNA検出

2020/12/24

Efficient detection of SARS-CoV-2 RNA in the solid fraction of wastewater.

Kouichi Kitamura, Kenji Sadamasu, Masamichi Muramatsu, Hiromu Yoshida.

ヒトサポウイルスの細胞培養増殖系の確立

2020/12/01

Human sapovirus propagation in human cell lines supplemented with bile acids.

Hirotaka Takagi, Tomoichiro Oka, Takashi Shimoike, Hiroyuki Saito, Takayuki Kobayashi, Tomoko Takahashi, Chika Read More

ヒト肝臓がん由来HuH-7及びHuh7.5.1-8細胞株における特徴的ゲノムマーカーの同定

2020/10/21

Identification of characteristic genomic markers in human hepatoma HuH-7 and Huh7.5.1-8 cell lines,

Kawamoto M, Yamaji T, Saito K, Shirasago Y, Satomura K, Endo T, Fukasawa M, Hanada K, and Read More

ヒトT細胞白血病ウイルス1型はキャリア妊婦の胎盤内において栄養膜細胞を標的とする

2020/10/20

HTLV-1 targets human placental trophoblasts in seropositive pregnant women.

Kenta Tezuka, Naoki Fuchi, Kazu Okuma, Takashi Tsukiyama, Shoko Miura, Yuri Hasegawa, Ai Nagata, Nahoko Komatsu, Read More

肺炎マイコプラズマの細胞接着装置：P1タンパク質複合体の構造解明

2020/10/15

Immunodominant proteins P1 and P40/P90 from human pathogen Mycoplasma pneumoniae.

David Vizarraga, Akihiro Kawamoto, U. Matsumoto, Ramiro Illanes, Rosa Pérez-Luque, Jesús Martín, Rocco M Read More

ウエスタンブロット法の代替法としてのラインブロット法を用いたヒトT細胞白血病ウイルス１型感染の新規診断検査アルゴリズムの確立：日本における診断検査性能評価のための共同研究

2020/08/27

Establishment of a novel diagnostic test algorithm for human T-cell leukemia virus type 1 infection with line immunoassay replacement of western blotting: a collaborative study for performance eval Read More

MARCH8は二つの異なるメカニズムでウイルス感染を抑制する

2020/08/26

MARCH8 inhibits viral infection by two different mechanisms.

Yanzhao Zhang, Takuya Tada, Seiya Ozono, Satoshi Kishigami, Hideaki Fujita, and Kenzo Tokunaga.

発光ペプチドタグを付加したHIV-1の超迅速な産生定量系の樹立

2020/08/26

Super-rapid quantitation of the production of HIV-1 harboring a luminescent peptide tag.

Seiya Ozono, Yanzhao Zhang, Minoru Tobiume, Satoshi Kishigami, and Kenzo Tokunaga.

過去40年間の肺炎マイコプラズマの流行菌型の周期的な変化

2020/08/07

Periodic genotype shifts in clinically prevalent Mycoplasma pneumoniae strains in Japan.

Kenri T, Suzuki M, Sekizuka T, Ohya H, Oda Y, Yamazaki T, Fujii H, Hashimoto T, Nakajima H, Katsukaw Read More

新型コロナウイルスSARS-CoV-2のゲノム分子疫学調査２ (2020/7/16現在)

2020/08/05

国立感染症研究所病原体ゲノム解析研究センター

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C型肝炎ウイルスの動態と感染最大化戦略 – ウイルスゲノムの複製、放出のバランス

2020/07/31

Should a viral genome stay in the host cell or leave? A quantitative dynamics study of how hepatitis C virus deals with this dilemma.

Iwanami S, Kitagawa K, Ohashi H, Asai Y, Shionoya K, Sa Read More

アボカドから分離された新規抗エンテロウイルスD68化合物

2020/06/25

Characterization of a new anti-enterovirus 68 compound purified from avocado.

Minetaro Arita, Hiroyuki Fuchino, Hitomi Kawakami, Masami Ezaki and Nobuo Kawahara

感染効率の良いB型肝炎ウイルスの細胞培養系の樹立

2020/05/25

N-terminal PreS1 Sequence Regulates Efficient Infection of Cell Culture-generated Hepatitis B Virus.

Asako Murayama, Norie Yamada, Yoshiki Osaki, Masaaki Shiina, Hussein Hassan Aly, Masashi Read More

ヒト肝がん由来Huh7.5.1-8細胞とアフリカミドリザル腎由来Vero細胞におけるフラビウイルス産生能の比較解析

2020/05/18

Comparative characterization of flavivirus production in two cell lines: Human hepatoma-derived Huh7.5.1-8 and African green monkey kidney-derived Vero.

Kyoko Saito, Masayoshi Fukasawa, Yos Read More

進行性多巣性白質脳症の組織におけるJCポリオーマウイルスがコードするマイクロRNAの高発現とそのウイルス複製における機能

2020/05/15

High expression of JC polyomavirus-encoded microRNAs in progressive multifocal leukoencephalopathy tissues and its repressive role in virus replication.

Kenta Takahashi, Yuko Sato, Tsuyoshi Read More

HTLV-1感染細胞を効率的に排除するための新しい治療アプローチとしてのPERK-ATF4-CHOP経路の活性化

2020/05/13

Activation of PERK-ATF4-CHOP pathway as a novel therapeutic approach for efficient elimination of HTLV-1–infected cells.

Emi Ikebe, Sahoko Matsuoka, Kenta Tezuka, Madoka Kuramitsu, Kazu O Read More

転写共役因子VGLL1は転写因子TEAD1を介してヒトパピローマウイルス初期遺伝子の転写を誘導する

2020/05/13

The Transcriptional Cofactor VGLL1 Drives Transcription of Human Papillomavirus Early Genes via TEAD1.

Mori S, Takeuchi T, Ishii Y, Kukimoto I

新型コロナウイルスSARS-CoV-2のゲノム分子疫学調査

2020/04/27

国立感染症研究所病原体ゲノム解析研究センター

原文PDF版の Read More

早期診断率に基づく日本国内HIV感染者数の推定

2020/04/27

Estimating HIV-1 incidence in Japan from the proportion of recent infections .

Matsuoka S, Nagashina M, Sadamasu K, Mori H, Kawahata T, Zaitsu S, Nakamura A, de Souza MS, Matano T.

自己免疫性の糖尿病はCD8陽性制御性T細胞によって抑制される

2020/04/23

CD8+ regulatory T cells play a critical role in prevention of autoimmune-mediated diabetes.

Chikako Shimokawa, Tamotsu Kato, Tadashi Takeuchi, Noriyasu Ohshima, Takao Furuki, Yoshiaki Ohtsu Read More

クラミジア・トラコマティスに感染したヒト細胞は、スフィンゴミエリン合成酵素１および２がなくてもセラミドをスフィンゴミエリンへと変換する

2020/04/16

Chlamydia trachomatis-infected human cells convert ceramide to sphingomyelin without sphingomyelin synthases 1 and 2.

Tachida Y, Kumagai K, Sakai S, Ando S, Yamaji T, and Hanada K

免疫不全ウイルス特異的CD8陽性T細胞を選択的に誘導する新規抗原設計

2020/04/07

A Novel Immunogen Selectively Eliciting CD8+ T Cells but Not CD4+ T Cells Targeting Immunodeficiency Virus Antigens.

Ishii H, Terahara K, Nomura T, Takeda A, Okazaki M, Yamamoto H, Tokusumi Read More

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研究情報 掲載記事一覧

Structural analyses of the GI.4 norovirus by cryo-electron microscopy and X-ray crystallography revealing binding sites for human monoclonal antibod Read More

Loxapine inhibits replication of hepatitis A virus in vitro and in vivo by targeting viral protein 2C

Pneumococcal sialidase promotes bacterial survival by fine-turning of pneumolysin-mediated membrane disruption

Enterovirus A71 does not meet the uncoating receptor SCARB2 at the cell surface

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Generation of JC Polyoma Pseudovirus for High‐Throughput Measurement of Neutralizing Antibodies

Structural basis of hepatitis B virus receptor binding

Infectious virus shedding duration reflects secretory IgA antibody response latency after SARS-CoV-2 infection

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Distribution of antimicrobial resistance and virulence genes within the prophage-associated regions in nosocomial pathogens

Machine learning-based motion tracking reveals an inverse correlation between adhesivity and surface motility of the leptospirosis spirochete

Rapid and sensitive on-site detection of SARS-CoV-2 RNA from environmental surfaces using portable laboratory devices

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Structural basis for cross-group recognition of an influenza virus hemagglutinin antibody that targets postfusion stabilized epitope

HTLV-1 Proliferation after CD8+ Cell Depletion by Monoclonal Anti-CD8 Antibody Administration in Latently HTLV-1-Infected Cynomolgus Macaques

Potential Anti-Mpox Virus Activity of Atovaquone, Mefloquine, and Molnupiravir, and Their Potential Use as Treatments

Identification of IMP Dehydrogenase as a Potential Target for Anti-Mpox Virus Agents

A bivalent outer membrane vesicle-based intranasal vaccine to prevent infection of periodontopathic bacteria

Genotyping of Mycoplasma pneumoniae strains isolated in Japan during 2019 and 2020: spread of p1 gene type 2c and 2j variant strains

CD62L expression marks SARS-CoV-2 memory B cell subset with preference for neutralizing epitopes

The C10orf76–PI4KB axis orchestrates CERT-mediated ceramide trafficking to the distal Golgi

Development of serological assays to identify Helicobacter suis and H. pylori infections.

Saturation time of exposure interval for cross-neutralization response to SARS-CoV-2: implications for vaccine dose intervalRead More

Dose-sparing effect of Sabin-derived inactivated polio vaccine produced in Japan by intradermal injection device for rats

Monitoring Enteroviruses and SARS-CoV-2 in Wastewater Using the Polio Environmental Surveillance System in Japan

National seroepidemiological study of COVID-19 after the initial rollout of vaccines: Before and at the peak of the Omicron-dominant period in Japan Read More

Non-Omicron breakthrough infection with higher viral load and longer vaccination-infection interval improves SARS-CoV-2 BA.4/5 Read More

Discovery of super–insecticide-resistant dengue mosquitoes in Asia: Threats of concomitant knockdown resistance mutationsRead More

A highly immunogenic vaccine platform against encapsulated pathogens using chimeric probiotic Escherichia coli membrane vesicl Read More

Establishment of Vero cell lines persistently harboring a yellow fever virus 17D subgenomic replicon

Macrophage depletion reactivates fecal virus shedding following resolution of acute hepatitis A in Ifnar1-/- mice

Essential domains of oxysterol-binding protein required for poliovirus replication

Membrane sphingomyelin in host cells is essential for nucleocapsid penetration into the cytoplasm after hemifusion during rubella virus entry

Oral and Rectal Colonization by Antimicrobial-Resistant Gram-Negative Bacteria and Their Association with Death among Residents of Long-Term Care Fa Read More

Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airways

High-throughput analysis of anti-poliovirus neutralization antibody titre in human serum by the pseudovirus neutralization test

Neutralization of Hepatitis B Virus with Vaccine-Escape Mutations by Hepatitis B Vaccine with Large-HBs Antigen.

COVID-19 vaccine effectiveness against symptomatic SARS-CoV-2 infection during Delta-dominant and Omicron-dominant periods in Japan: a multi-center Read More

Social and Behavioral Factors Associated with Lack of Intent to Receive COVID-19 Vaccine, Japan

Significant role of host sialylated glycans in the infection and spread of severe acute respiratory syndrome coronavirus 2

Structural insights into the HBV receptor and bile acid transporter NTCP

Fungal Secondary Metabolite Exophillic Acid Selectively Inhibits the Entry of Hepatitis B and D Viruses

Ligand recognition by the lipid transfer domain of human OSBP is important for enterovirus replication

Vaccination-infection interval determines cross-neutralization potency to SARS-CoV-2 Omicron after breakthrough infection by other variants

Env-independent protection of intrarectal SIV challenge by vaccine induction of Gag/Vif-specific CD8+ T cells but n Read More

Distinct immune cell dynamics correlate with the immunogenicity and reactogenicity of SARS-CoV-2 mRNA vaccine

Induction of neutralizing antibodies against hepatitis C virus by a subviral particle-based DNA vaccine

Activities of endogenous APOBEC3s and uracil-DNA-glycosylase affect the hypermutation frequency of hepatitis B virus cccDNA

Sendai virus particles carrying target virus glycoproteins for antibody induction

Neutralizing-antibody-independent SARS-CoV-2 control correlated with intranasal-vaccine-induced CD8+ T cell responses

Lewis fucose is a key moiety for the recognition of histo-blood group antigens by GI.9 norovirus, as revealed by structural analysis

SARS-CoV-2 Omicron-neutralizing memory B-cells are elicited by two doses of BNT162b2 mRNA vaccine

Dasabuvir Inhibits Human Norovirus Infection in Human Intestinal Enteroids

A lethal mouse model for evaluating vaccine-associated enhanced respiratory disease during SARS-CoV-2 infection

MARCH8 targets cytoplasmic lysine residues of various viral envelope glycoproteins

Nasal alum-adjuvanted vaccine promotes IL-33 release from alveolar epithelial cells that elicits IgA production via type 2 immu Read More

M-Sec induced by HTLV-1 mediates an efficient viral transmission

A SARS-CoV-2 Antibody Broadly Neutralizes SARS-related Coronaviruses and Variants by Coordinated Recognition of a Virus Vulnerable Site

Seroprevalence of Flavivirus Neutralizing Antibodies in Thailand by High-Throughput Neutralization Assay: Endemic Circulation of Zika Virus before 2 Read More

Impact of the COVID-19 pandemic on the surveillance of antimicrobial resistance

High-order epistasis and functional coupling of infection steps drive virus evolution toward independence from a host pathway

Amino Acid Polymorphism in Hepatitis B Virus Associated with Functional Cure.

Subacute SARS-CoV-2 replication can be controlled in the absence of CD8+ T cells in cynomolgus macaques.

Temporal Maturation of Neutralizing Antibodies in COVID-19 Convalescent Individuals Improves Potency and Breadth to Circulating SARS-CoV-2 Variants< Read More

Dysbiotic fecal microbiome in HIV-1 infected individu Read More

Identification of Anti-Severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Oxysterol Derivatives In Vitro

Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment

Mefloquine, a Potent anti-Severe Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2) drug as an entry inhibitor in vitro

Interferon signaling suppresses the unfolded protein response and induces cell Read More

Identification of two critical neutralizing epitopes in the receptor binding do Read More

The physiological TMPRSS2 inhibitor HAI-2 alleviates SARS-CoV-2 infection

A highly attenuated vaccinia virus strain LC16m8-based vaccine for severe fever with thrombocytopenia syndrome.

研究情報　掲載記事一覧

Macrophage depletion reactivates fecal virus shedding following resolution of acute hepatitis A in Ifnar1^-/- mice

Env-independent protection of intrarectal SIV challenge by vaccine induction of Gag/Vif-specific CD8⁺ T cells but n Read More